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Anti-Inflammatory and Hepatoprotective Activity of Peh-Hue-Juwa-Chi-Cao in Male Rats

Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung, Taiwan, R.O.C.

Correspondence to: Dr. C.-C. Lin, Graduate Institute of Natural Products, Kaohsiung Medical University, 100 Shih Chuan 1st Road, Kaohsiung, Taiwan 807, R.O.C.

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Lean-Teik Ng

Department of Food Technology, Ta-Jen Institute of Technology, Ping-Tung, Taiwan, R.O.C.

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Jenq-Jer Yang

Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung, Taiwan, R.O.C.

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, and

Yu-Fang Hsu

Department of Pharmacy, Kaohsiung Municipal Women and Children General Hospital, Kaohsiung, Taiwan, R.O.C.

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https://doi.org/10.1142/S0192415X02000405Cited by:46 (Source: Crossref)

Abstract

Peh-Hue-Juwa-Chi-Cao (PHJCC) is a common commercial name for the herbal extract of either Hedyotis diffusa (HD), H. corymbosa (HC), or Mollugo pentaphylla (MP). The present study was carried out to investigate the anti-inflammatory and hepatoprotective effects of these three extracts in rats. The results indicated that extracts of HC, HD and MP possess anti-inflammatory activity, and that MP has the greatest inhibition against carrageenan-induced paw edema. In the hepatoprotective study, results indicated that the three plant extracts significantly reduced the acute elevation of serum glutamate oxalate transaminase (sGOT) and serum glutamate pyruvate transaminase (sGPT) concentration, and alleviated the degree of liver damage 24 hours after the intraperitoneal administration of hepatotoxins.

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