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Core–Shell γ-Fe₂O₃/SiO₂/PCA/Ag-NPs Hybrid Nanomaterials as a New Candidate for Future Cancer Therapy

Polymer Science and Technology Division, Research Institute of Petroleum Industry (RIPI), Tehran, Iran

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Polymer Research Laboratory, Department of Chemistry, Sharif University of Technology, Tehran, Iran

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Polymer Research Laboratory, Department of Chemistry, Sharif University of Technology, Tehran, Iran

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Polymer Science and Technology Division, Research Institute of Petroleum Industry (RIPI), Tehran, Iran

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https://doi.org/10.1142/S0219581X14500082Cited by:2 (Source: Crossref)

Abstract

In the current study, γ-Fe₂O₃/SiO₂/PCA/Ag-NPs hybrid nanomaterials were successfully synthesized and characterized. At first, prepared γ-Fe₂O₃ core nanoparticles were modified by SiO₂ layer. Then they were covered by poly citric acid (PCA) via melting esterification method as well. PCA shell acts as an effective linker, and provides vacancies for conveying drugs. Moreover, this shell as an effective capping agent directs synthesis of silver nanoparticles (Ag-NPs) via in situ photo-reduction of silver ions by sunlight-UV irradiation. This system has several benefits as a suitable cancer therapy nanomaterial. Magnetic nanoparticles (MNPs) can guide Ag-NPs and drugs to cancer cells and then Ag-NPs can affect those cells via Ag-NPs anti-angiogenesis effect. Size and structure of the prepared magnetic hybrid nanomaterials were characterized using FTIR and UV-Vis spectra, AFM and TEM pictures and XRD data.

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Vol. 13, No. 01

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History

Received 4 April 2012

Accepted 3 March 2014

Published: 3 April 2014

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