No Access

Photochemical Properties of Water-soluble Fluorinated Zinc Phthalocyanines and their Photocytotoxicity Against HeLa Cells

KAORU FUKUSHIMA

Department of Bioengineering, Tokyo Institute of Technology, Nagatsuta, Midori-ku, Yokohama 226, Japan

Search for more papers by this author

KENJI TABATA

Department of Bioengineering, Tokyo Institute of Technology, Nagatsuta, Midori-ku, Yokohama 226, Japan

Search for more papers by this author

, and

ICHIRO OKURA

Department of Bioengineering, Tokyo Institute of Technology, Nagatsuta, Midori-ku, Yokohama 226, Japan

Corresponding author, Department of Bioengineering, Tokyo Institute of Technology, Nagatsuta, Midori-ku, Yokohama 226, Japan.

Search for more papers by this author

https://doi.org/10.1002/(SICI)1099-1409(199805/06)2:3<219::AID-JPP66>3.0.CO;2-GCited by:16 (Source: Crossref)

Abstract

Three types of amphiphilic water-soluble fluorinated zinc phthalocyanines are characterized. They have absorption bands at long wavelength, which cause greater penetration depth of a tissue. The uptake and photodynamic activity of the phthalocyanines against HeLa cells were measured, showing that the phthalocyanines exhibited higher photodynamic activities than zinc tetrasulfonated phthalocyanine.

Keywords:

Most comprehensive & up-to-date research on PORPHYRINS
Handbook of Porphyrin Science now available in 46 volumes

References

D. Kessel, Spectrum 3, 13 (1990). Web of Science, Google Scholar
S. Wanet al., Photochem. Photobiol. 34, 679 (1981). Web of Science, Google Scholar
D. Wöhrleet al., Russ. Chem. Bull. 43, 1953 (1994). Web of Science, Google Scholar
P. Margaron, R. Langlois and J. E. van Lier, J. Photochem. Photobiol. B 14, 187 (1992), DOI: 10.1016/1011-1344(92)85097-E. Web of Science, Google Scholar
T. Takenoet al., Lasers in the Life Sciences 6, 173 (1994). Web of Science, Google Scholar
J. H. Weber and D. H. Busch, Inorg. Chem. 4, 469 (1996), DOI: 10.1021/ic50026a007. Web of Science, Google Scholar
G. Valdugaet al., Photochem. Photobiol. 48, 1 (1988). Web of Science, Google Scholar
O. H. Lowryet al., J. Biol. Chem. 193, 265 (1951). Web of Science, Google Scholar
J. Carmichaelet al., Cancer Res. 47, 936 (1987). Web of Science, Google Scholar
P. Margaronet al., Photochem. Photobiol. 63, 217 (1996), DOI: 10.1111/j.1751-1097.1996.tb03017.x. Web of Science, Google Scholar
J. R. Wangeret al., Photochem. Photobiol. 45, 587 (1987). Web of Science, Google Scholar
J. R. Boyleet al., Photochem. Photobiol. 64, 469 (1996), DOI: 10.1111/j.1751-1097.1996.tb03093.x. Web of Science, Google Scholar
D. Wöhrleet al., J. Macromol. Sci. Chem. A 25, 1227 (1988). Web of Science, Google Scholar