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Preparation of monofunctional and phosphorescent palladium(II) and platinum(II) coproporphyrin labeling reagents

Laboratory of Biophysics, Institute of Biomedicine, University of Turku, PO Box 123, 20521 Turku, Finland

Corresponding author, Laboratory of Biophysics, Institute of Biomedicine, University of Turku, PO Box 123, 20521 Turku, Finland.

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DMITRI V. YASHUNSKY

Institute of Biomedical Chemistry RAMS, Moscow 119832, Russia

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NIKO J. MELTOLA

Laboratory of Biophysics, Institute of Biomedicine, University of Turku, PO Box 123, 20521 Turku, Finland

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, and

GELII V. PONOMAREV

Institute of Biomedical Chemistry RAMS, Moscow 119832, Russia

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https://doi.org/10.1002/jpp.385Cited by:15 (Source: Crossref)

Abstract

A method is described for preparation of monosubstituted derivatives of platinum and palladium coproporphyrin-I. The method is based on chemical differentiation of one of the four alkoxycarbonyl groups of the starting coproporphyrin-I tetraalkyl ester by selective acid hydrolysis. The hydrolysis results after chromatographic purification to pure mono hydroxycarbonyl coproporphyrin, which can be subsequently coupled with a chemical species carrying a functional group of interest. The described method is used for preparation of phosphorescent metalloporphyrin labeling reagents having an isothiocyanato reactive group.

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