Platelet Biology: The Role of Platelets in Hemostasis, Thrombosis and Inflammation

The following sections are included:

• Introduction

• Platelet: Structural Anatomy

  • Peripheral zone

    • Exterior coat

    • Platelet unit membrane

    • Submembrane region

  • Sol-gel zone

  • Organelle zone

  • Membrane system

• Platelet: Functional Anatomy

  • Platelet adhesion

  • Platelet activation

    • COAT platelets

  • Platelet secretion

    • The platelet ADP receptor

    • Binding

    • Mechanisms of action

    • ADP receptors on other cells

  • Platelet aggregation

    • Cell-based model of coagulation

    • Platelet-leukocyte interactions

    • Platelet-derived mediators

    • Neutrophil-derived mediators

    • Platelet-leukocyte adhesion

• Inflammation and Thrombosis

• Platelet RNA and Proteomics

• Summary

• References