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Nephrogenic Systemic Fibrosis: A Prototype Fibrocyte Disease

    https://doi.org/10.1142/9789812706690_0011Cited by:1 (Source: Crossref)
    Abstract:

    The following sections are included:

    • Introduction

    • Historical Context

    • The Affected Population

      • Renal Disease

      • Dialysis

      • Renal transplantation

      • Other Comorbidities

        • Hypercoagulability, thrombosis, and endothelial injury

        • Other systemic processes

    • Presentation

      • Signs, Symptoms and Progression

      • Diagnosis

        • Laboratory investigation

        • Biopsy and histopathology

        • Ancillary studies

      • Treatment

        • Renal transplantation

        • Extracorporeal photopheresis (ECP)

        • Plasmapheresis

        • Other considerations

    • Discussion

      • Circulating Fibrocytes

        • A basic conceptual model and possible triggers

        • The newest suspect: Endothelin-I

        • Fibrosis via accretion — a proposal

        • Fibrosis via exogenous substances — an alternate hypothesis

    • Acknowledgment

    • References