Neoadjuvant/Adjuvant/Chemoprevention Therapy and Tumor Downstaging

The following sections are included:

• Introduction

• Neoadjuvant/Adjuvant/Chemoprevention Therapy in Liver Resection for HCC

  • Neoadjuvant transarterial chemoembolization (TACE)

  • Adjuvant regional chemotherapy with or without embolization

    • Adjuvant regional therapy

    • Adjuvant regional and systemic therapy

    • Neoadjuvant plus adjuvant regional therapy

  • Adjuvant systemic chemotherapy

  • Adjuvant transarterial radioembolization (TARE)

  • Adjuvant immunotherapy

  • Chemoprevention with vitamin analog therapy after curative liver resection

• Neoadjuvant/Adjuvant Therapy in Liver Transplantation for HCC

  • Neoadjuvant TACE

  • Neoadjuvant local ablative therapy

  • Neoadjuvant multimodality therapy

  • Neoadjuvant/Adjuvant systemic chemotherapy

• Salvage Surgery After Tumor Downstaging of Advanced HCC

  • Indication and prerequisites for salvage surgery and tumor downstaging

  • Rationale for salvage surgery after successful tumor downstaging

  • Results of salvage surgery after tumor downstaging

    • Tumor downstaging with TACE

    • Tumor downstaging with TAC

    • Tumor downstaging with multimodality therapy

  • Challenges of tumor downstaging

  • Prognosis and survival

• References