The Contribution of Structural Proteomics to Understanding the Function of Hypothetical Proteins

Developments in structural genomics have led to the automation of protein production and given rise to the structure determination pipeline, resulting in a rapid increase in the number of new protein structures. The next challenge will be to infer the functions for many of these proteins. Here, we describe the efforts of the Montreal-Kingston Bacterial Structural Genomics Initiative in the utilization of structural information for protein functional assignment as illustrated by several examples.