Linkage Disequilibrium and Test for Interaction Between Two Loci

The following sections are included:

• INTRODUCTION

• TEST FOR INTERACTION BETWEEN TWO LOCI

  • Introduction

  • Linkage Disequilibrium Generated by Gene–Gene Interactions

  • Measure of Interaction between Genes

  • Relationships between Interaction Measure and Traditional Quantitative Genetic Effects

• INTERACTION BETWEEN TWO UNLINKED LOCI

  • Linkage Disequilibrium Generated by Interaction between Two Unlinked Loci

  • Indirect Interaction between Two Unlinked Marker Loci

  • Test Statistic

  • Patterns of Pairwise LD under Two-Locus Disease Models

  • Pairwise Interaction Measure

  • Null Distribution of Test Statistics

  • Power Evaluation

  • Application to a Real Data Example

• COMPOSITE MEASURE OF LINKAGE DISEQUILIBRIUM FOR DETECTION OF INTERACTION BETWEEN TWO LOCI

  • A General Model for Interaction Between Two Loci Including Two Genes at the Same Gamete or Different Gametes

  • Indirect Interaction between Two Unlinked Marker Loci

  • Test Statistic

  • Null Distribution of Test Statistics

  • Application to a Real Data Example

• CONCLUSIONS

  • Appendix A

  • Appendix B

  • Appendix C

  • Appendix D

• REFERENCES