EXPERIMENTAL PHARMACOLOGICAL RESEARCHES CONCERNING VEGETAL EXTRACTS IN HIGH DILUTIONS: I. CHAMOMILLA, IN VIVO, ON CENTRAL NERVOUS SYSTEM, AT THE “SENSITIVE” MICE

Low degree centesimal dilution, 5 CH, and high degree centesimal dilution, 30 CH, have been prepared, starting from tincture of Chamomilla (Cham), by succesive water dilution at a 1 : 100 rate and dynamisation (D), according to Hahnemann technique. The treatment was made per os. The effects of C dilutions, on central nervous systems (CNS), were studied. The blind screening methodology, used in experimental pharmacology, for CNS action investigation, on mice, was utilised. The effects on both “normal” and “sensitive” healthy individuals were investigated. In order to select the “sensitive” to Cham drug-type, an original procedure was used. The actometric test, which has lead to divide the animal collectivity, according to Gauss bell-shaped distribution curve, in individuals with medium spontaneous motor activity (“normals”) and in individuals with hypo- or hypermotility (“sensitive”), was chosen. The effects noticed in these researches have had, without exception, a highly statistical significance (p < 0.01) in “sensitive” extreme individuals and have been statistically insignificant (p > 0.05) in “resistant” extreme individuals. In the author's opion, the extreme individuals, within a population with normal Gauss-like biological variability, represent psycho-neuro-endocrine typologies with opposite dominants, which should make the object of future biological and pharmacological studies.