DOSE RESPONSE IN A HIGH DILUTION OF AGARICUS MUSCARIUS L ON ALBINO MICE

Agaricus muscarius 30s, a potentized drug prepared by successive dilution with 90% alcohol followed by sonication, when given through oral route, suppressed haloperidol-induced catalepsy in Swiss albino mice significantly. This anticataleptic effect was dose dependent being maximum with the undiluted Agaricus 30s and minimum with its dilution 1:20,000. Higher dilutions like 1:40,000 and 1:50,000 did not produce any anticataleptic effect. The effect reappeared when the dilution 1:50,000 was sonicated. An amount of 0.05 ml of the dilution 2X10⁻⁴ of Agaricus 30s is quantitatively equivalent to 0.075 ml of the dilution 3X10⁻⁴ and to 0.16ml of the dilution 4x10⁻⁴. Three groups of mice were pretreated with the three dilutions of Agaricus 30s in such a way that each group received an equivalent volume dose of the drug. Of the three dilutions, only the lowest one 2x10⁻⁴ was effective in reducing haloperidol has an active physical entity which can be attenuated by dilution and multiplied by mechanical agitation or sonication. It is also suggested that potentized Agaricus acts through tongue receptors.