SD Rat Liver 9-dehydro-17-hydro-andrographolide Concentration Control Based on Calculative Optimization PID

In this paper, we use the PID control algorithm based on the calculative optimization method to control the concentration of the 9-dehydro-17-hydro-andrographolide administered to the liver of SD rats. Through data processing and with the assistance of the polynomial fitting function in MATLAB, we obtained a fitting analysis by using the 9-dehydro-17-hydro-andrographolide distribution data in SD rats’ liver tissues and achieving a close fitting effect. Based on the fitting function obtained, we can not only design the PID control system and calculate the PID controller parameters that content of the sensitivity index, but also utilize the PID algorithm to attain the effect of the expected model. The mathematical model that we developed is clear and accurate, it can reflect the dynamic changes law of the drug in the body, from which, we can observe and analyzes the input-output curves to draw accurate conclusions. Simulation results demonstrate that the control algorithm has relatively high adaptability and robustness, and we can obtain better control effects.