Study on biology properties of the bioceramic coating on titanium alloy by cold spraying

It is crucial to find a kind of method with environment protection, economics, high efficiency and feasibility to prepare the HA coating on the surface of the titanium and its alloy. In this study, a novel method, the high speed high pressure cold spraying was employed to prepare the HA coating on the surface of TC4 (a kind of titanium alloy). The cytotoxicity behaviors of coating and titanium alloy substrate were investigated. Hydroxyapatite-zirconia (HA-ZrO2) coating was deposited on TC4 titanium alloy substrate by cold spray (CS). According to the performances of the activity detection of the alkaline phosphatase (ALP) and the activities of aminopherase on the surface of the coating, the biology properties of coatings and substrate were investigated. The results show that the contents of neutyophil alkaline phosphatase on the surface of coating are much more than that on the surface of titanium alloy substrate. In addition, the absorption capacity data of albumin and fibronectin of the coating are much better obviously than that of the titanium substrate. The results indicate that the biology properties of the coating are much better than that of the substrate.