Chapter 4: Silent Synapse

The following sections are included:

• News and Views

• Summary

• Introduction

• Spinal LTP

• Spinal sensitization and synaptic potentiation

• Spinal LTP caused by peripheral injury

• Early studies of ineffective synapses in the spinal cord

• Silent glutamatergic synapses in the spinal cord dorsal horn

• Silent synaptic transmission and silent glutamatergic synapses

• Recruitment of silent synapses

• Intracellular mechanisms for 5-HT-induced facilitation

• AMPA receptor and the expression of facilitation

• Coactivation of cAMP signaling pathways in facilitation of adult sensory synapses

• Implications for silent synapses and LTP in pathological or chronic pain

• Behavioral studies of GluR2 interfering peptides

• Conclusions and future perspectives

• References