Rules and Regulations for Carrying Out Animal Research Work

The following sections are included:

• Animal Research Ethics

  • Rules and regulations

  • Responsibilities

  • Training and education

• Laws and Guidelines

  • Animal Welfare Act 1966, USA

  • Public Health Service Policy on Humane Care and Use of Laboratory Animals 1985, USA

  • Guide for the Care and Use of Laboratory Animals, USA

  • Good Laboratory Practice, USA/OECD

  • Controlled Substances Act, USA

  • American Veterinary Medical Association Panel on Euthanasia, USA

  • Guide for the Care and Use of Agricultural Animals in Agriculture Research and Teaching, USA

  • Animals (Scientific Procedures) Act 1986, UK

  • Protection of Animals Act 1911, UK

  • Medicines Act 1968, UK

  • Federation of European Laboratory Animal Science Associations (FELASA) guidelines and recommendations, EU

  • Council Directive 86/609/EEC, EU

  • Animals and Birds (Care and Use of Animals for Scientific Purposes) Rules 2004, Singapore

  • NACLAR Guidelines, Singapore

• Accreditation of Animal Research Facilities

  • Association for the Assessment and Accreditation of Laboratory Animal Care (AAALAC) International

  • AAALAC's Board of Trustees

  • Council on Accreditation

  • Ad hoc consultants

  • Regulations and policies

  • AAALAC evaluation

  • References referred to by AAALAC

  • Why AAALAC's role is important

• The 3 R's — Replace, Reduce, Refine

  • The 3 R's

    • Replace

    • Reduce

    • Refine

  • Ethical responsibilities of a researcher

  • Responsibilities of investigators

  • Public concern

  • The use of alternatives

    • Why consider alternatives?

      • Regulatory compliance

      • Social and humane considerations

      • Economic factors

      • Scientific considerations

  • Search evaluation — the principal investigator's role

• Institutional Animal Care and Use Committee (IACUC)

  • Responsibilities

  • IACUC's main functions

    • Facility inspections — reviewed every 6 months

  • Evaluation of animal welfare concerns

  • Review of applications for the use of experimental animals

  • Responsibilities of researchers

  • Application for the use of experimental animals — submissions

  • USDAf Reportable Pain Categories (CFR Ch.1, 2.36(b) (5–7))

  • Requirements for staff qualification and training

  • Health and safety of personnel

  • New and renewal protocols

    • New protocols

    • Amendments

  • Planning projects

• Project Licence Application Tips — How to Write an IACUC Application

  • Project licence/IACUC application

  • Assessment of benefit and severity

  • Assessment of pain and distress

  • Humane endpoints

  • Reuse of animals

  • Other factors taken into account in considering project licence applications

  • Responsibilities of the project licence holder

  • Deputy project licence holder/Contact person

  • Project licence/IACUC application for education and training

  • Use of biohazards/radioisotopes