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CORTICAL EXCITABILITY AND REFRACTORY EPILEPSY: A THREE-YEAR LONGITUDINAL TRANSCRANIAL MAGNETIC STIMULATION STUDY

RADWA A. B. BADAWY

Department of Neurology, Austin Health, Heidelberg, Epilepsy Research Centre, Australia

Department of Medicine, University of Melbourne, Brain Research Institute, Australia

Florey Neuroscience Institutes Heidelberg West, Victoria, Australia

Corresponding author.

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GRAEME D. JACKSON

Department of Neurology, Austin Health, Heidelberg, Epilepsy Research Centre, Australia

Department of Medicine, University of Melbourne, Brain Research Institute, Australia

Florey Neuroscience Institutes Heidelberg West, Victoria, Australia

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SAMUEL F. BERKOVIC

Department of Neurology, Austin Health, Heidelberg, Epilepsy Research Centre, Australia

Department of Medicine, University of Melbourne, Brain Research Institute, Australia

Florey Neuroscience Institutes Heidelberg West, Victoria, Australia

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, and

RICHARD A. L. MACDONELL

Department of Neurology, Austin Health, Heidelberg, Epilepsy Research Centre, Australia

Department of Medicine, University of Melbourne, Brain Research Institute, Australia

Florey Neuroscience Institutes Heidelberg West, Victoria, Australia

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https://doi.org/10.1142/S012906571250030XCited by:60 (Source: Crossref)

Abstract

Transcranial magnetic stimulation was used to study the effect of recurrent seizures on cortical excitability over time in epilepsy. 77 patients with firm diagnoses of idiopathic generalized epilepsy (IGE) or focal epilepsy were repeatedly evaluated over three years. At onset, all groups had increased cortical excitability. At the end of follow-up the refractory group was associated with a broad increase in cortical excitability. Conversely, cortical excitability decreased in all seizure free groups after introduction of an effective medication.

Keywords:

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