Proceedings of the 25th Symposium on PIXE in Japan (The 16th Annual Meeting of the Japan Society for Particle Induced X-ray Emission (PIXE) Research), Maebashi, 10–12 September 2008; Guest Editor: T. Nagamine (School of Health Sciences, Faculty of Medicine, Gunma University)No Access

3D IMAGING OF HUMAN CELLS BY USING PIXE-µ-CT

Y. KAWAMURA

Department of Quantum Science and Energy Engineering, Tohoku University, Sendai 980-8579, Japan

Search for more papers by this author

K. ISHII

Department of Quantum Science and Energy Engineering, Tohoku University, Sendai 980-8579, Japan

Search for more papers by this author

S. MATSUYAMA

Department of Quantum Science and Energy Engineering, Tohoku University, Sendai 980-8579, Japan

Search for more papers by this author

M. NAKHOSTIN

Department of Quantum Science and Energy Engineering, Tohoku University, Sendai 980-8579, Japan

Search for more papers by this author

M. FUJIWARA

Department of Quantum Science and Energy Engineering, Tohoku University, Sendai 980-8579, Japan

Search for more papers by this author

M. WATANABE

Department of Quantum Science and Energy Engineering, Tohoku University, Sendai 980-8579, Japan

Search for more papers by this author

S. OKURA

Department of Quantum Science and Energy Engineering, Tohoku University, Sendai 980-8579, Japan

Search for more papers by this author

N. HAMADA

Department of Quantum Science and Energy Engineering, Tohoku University, Sendai 980-8579, Japan

Search for more papers by this author

S. TSUBOI

Department of Quantum Science and Energy Engineering, Tohoku University, Sendai 980-8579, Japan

Search for more papers by this author

K. YAMANAKA

Department of Quantum Science and Energy Engineering, Tohoku University, Sendai 980-8579, Japan

Search for more papers by this author

Y. HASHIMOTO

Department of Quantum Science and Energy Engineering, Tohoku University, Sendai 980-8579, Japan

Search for more papers by this author

M. FUJIKAWA

Department of Quantum Science and Energy Engineering, Tohoku University, Sendai 980-8579, Japan

Search for more papers by this author

G. CATELLA

Department of Quantum Science and Energy Engineering, Tohoku University, Sendai 980-8579, Japan

Search for more papers by this author

Y. HATORI

Department of Quantum Science and Energy Engineering, Tohoku University, Sendai 980-8579, Japan

Search for more papers by this author

K. FUJIKI

Department of Quantum Science and Energy Engineering, Tohoku University, Sendai 980-8579, Japan

Search for more papers by this author

H. YAMAZAKI

Cyclotron Radioisotope Center, Tohoku University, Sendai 980-8578, Japan

Search for more papers by this author

R. ORTEGA

CNAB, CNRS Universite Bordeaux 1, BP120 Le Haut Vigneau, 33175 Gradignan, France

Search for more papers by this author

G. DEVES

CNAB, CNRS Universite Bordeaux 1, BP120 Le Haut Vigneau, 33175 Gradignan, France

Search for more papers by this author

, and

A. CARMONA

CNAB, CNRS Universite Bordeaux 1, BP120 Le Haut Vigneau, 33175 Gradignan, France

Search for more papers by this author

https://doi.org/10.1142/S0129083509001710Cited by:5 (Source: Crossref)

Abstract

Particulate matter (PM) such as chromium compound (PbCrO₄) is highly cytotoxic and carcinogenic. Several hexavalent chromium, compounds, Cr (VI), compounds are known to generate hydroxyl radical with in the cell and contribute to tissue damage. The way that theses compounds interact with human bodies at a cellular level is still unknown. To investigate the intracellular mechanism of chromium compounds, the 3D imaging techniques at the micro level are needed. In this paper, we report on the improvement of the PIXE-µ-CT system which was developed at Tohoku University and measured intracellular distribution images of PbCrO_4.particles on human lung cell.

Keywords:

References

R. Ortegaet al., Nuclear Instruments and Methods B 210, 325 (2003), DOI: 10.1016/S0168-583X(03)01056-5. Web of Science, Google Scholar
R. Ortegaet al., Journal de Physique IV 104, 289 (2003), DOI: 10.1051/jp4:200300082. Google Scholar
R. Ortegaet al., Chemical Research in Toxicology (Marcel Dekker Inc., New York, 2005) pp. 35–68. Google Scholar
K. Ishiiet al., Int. J. PIXE 15(4), 111 (2005), DOI: 10.1142/S0129083505000416. Link, Google Scholar
T. Yamaguchiet al., Int. J. PIXE 15(4), 195 (2005), DOI: 10.1142/S0129083505000519. Link, Web of Science, Google Scholar
K. Ishiiet al., Nucl. Instr. Meth. B 249, 726 (2006), DOI: 10.1016/j.nimb.2006.03.127. Web of Science, Google Scholar
K. Ishiiet al., Nucl. Instr. Meth. A 571, 64 (2007), DOI: 10.1016/j.nima.2006.10.030. Web of Science, Google Scholar
Y. Kawamuraet al., Int. J. PIXE 17(2), 41 (2007), DOI: 10.1142/S0129083507001083. Link, Web of Science, Google Scholar
S. Ohkuraet al., Int. J. PIXE 18(4), 167 (2008). Link, Google Scholar
K. Ishii and S. Morita, Int. J. PIXE 1, 1 (1990), DOI: 10.1142/S0129083590000025. Link, Google Scholar