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POLARITY-DRIVEN GEOMETRICAL CLUSTER GROWTH MODEL OF BUDDING YEAST

RENIEL B. CABRAL

National Institute of Physics, University of the Philippines, Diliman, 1101 Quezon City, Philippines

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and

National Institute of Physics, University of the Philippines, Diliman, 1101 Quezon City, Philippines

Corresponding author.

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https://doi.org/10.1142/S0129183110015749Cited by:1 (Source: Crossref)

Abstract

We present a polarity-driven activator-inhibitor model of budding yeast in a two-dimensional medium wherein impeding metabolites secretion (or growth inhibitors) and growth directionality are determined by the local nutrient level. We found that colony size and morphological features varied with nutrient concentration. A branched-type morphology is associated with high impeding metabolite concentration together with a high fraction of distal budding, while opposite conditions (low impeding metabolite concentration, high fraction of proximal budding) promote Eden-type patterns. Increasing the anisotropy factor (or polarity) produced other spatial patterns akin to the electrical breakdown under varying electric field. Rapid changes in the colony morphology, which we conjecture to be equivalent to a transition from an inactive quiescent state to an active budding state, appeared when nutrients were limited.

Keywords:

PACS: 87.18.Hf, 87.23.Cc

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Journal cover image

Vol. 21, No. 09

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History

Received 16 July 2010

Accepted 13 August 2010

Keywords