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Clinical Efficacy of EH0202, a Kampo Formula, on the Health of Middle-Aged Women

Department of Obstetrics and Gynecology, Osaka Medical College Takatsuki, Osaka 569-8686, Japan

Correspondence to: Dr. Takahisa Ushiroyama, Department of Obstetrics and Gynecology, Osaka Medical College, 2-7 Daigaku-machi, Takatsuki, Osaka 569-8686, Japan. Tel: (+81) 72-683-1221, Fax: (+81) 72-681-3723.

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Satoshi Yoshida

Product Category Management Institute for Consumer Healthcare Yamanouchi Pharmaceutical Co., Ltd., Tokyo, Japan

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Keiichi Tadaki

Medical Information, Marketing Division, SANWELL Co., Ltd., Tokyo, Japan

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Atsushi Ikeda

Department of Obstetrics and Gynecology, Osaka Medical College Takatsuki, Osaka 569-8686, Japan

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, and

Minoru Ueki

Department of Obstetrics and Gynecology, Osaka Medical College Takatsuki, Osaka 569-8686, Japan

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https://doi.org/10.1142/S0192415X04002314Cited by:5 (Source: Crossref)

Abstract

To investigate the clinical effects of EH0202, a Japanese herbal supplement, on the menopausal symptoms and physical status of peri- and post-menopausal women. Thirty-two post-menopausal women (53.0±5.1 years) presented with menopausal complaints were enrolled in the clinical study. Patients were administered an herbal supplement, EH0202 (6 g/day for 6 months), and were assessed for improvement of their overall symptoms using the Greene Climacteric Scale and the Visual Analog Scale (VAS). Blood pressure, skin surface blood flow and plasma lipid profiles were measured before and 1, 3 and 6 months after EH0202 administration. There was a significant decrease in the climacteric scale score (P<0.001) and VAS (P<0.0001) after 6 months of EH0202 treatment. There was a significant decrease in systolic (P<0.001) and diastolic (P<0.05) blood pressure, and a significant decrease in facial skin surface blood flow (P<0.05) after 3 months of EH0202 administration. We observed a significant decrease in plasma TG and LDL-cholesterol concentrations after 3 months of EH0202 administration (P<0.05). EH0202 (MACH) reduced blood pressure, excess facial skin blood flow (flushing) and abnormal lipid levels, as well as clinically improved menopausal symptoms in post-menopausal women. In post-menopausal women, this product appears to help maintain normal biological function and improves quality of life.

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References

T. Abeet al., Tohoku J. Exp. Med. 143, 481 (1984). Medline, Web of Science, Google Scholar
P. Albretazziet al., Obstet. Gynecol. 94, 229 (1999). Medline, Web of Science, Google Scholar
C. C. Allainet al., Clin. Chem. 20, 470 (1974). Medline, Web of Science, Google Scholar
American College of Obstetricians and Gynecologists Committee on Practice Bulletins (ACOG Practice Bulletin) Obstet. Gynecol. 97(), 1 (2001). Medline, Web of Science, Google Scholar
G. Bucolo and H. David, Clin. Chem. 19, 476 (1973). Medline, Web of Science, Google Scholar
B. Cengizet al., Maturitas 46, 301 (2003). Medline, Web of Science, Google Scholar
N. Chansueet al., Fish Pathol. 35, 89 (2000). Web of Science, Google Scholar
A. A. Ewies, Obstet. Gynecol. Surv. 56, 642 (2001). Medline, Web of Science, Google Scholar
W. T. Friedewald, R. I. Levy and D. S. Frederikson, Clin. Chem. 18, 499 (1972). Medline, Web of Science, Google Scholar
M. Gambaccianiet al., Maturitas 45, 175 (2003). Medline, Web of Science, Google Scholar
J. G. Greene, J. Psychosom. Res. 20, 425 (1976). Medline, Web of Science, Google Scholar
J. G. Greene, Maturitas 29, 25 (1998). Medline, Web of Science, Google Scholar
C. J. Haineset al., Maturitas 45, 169 (2003). Medline, Web of Science, Google Scholar
L. Holmberg and H. Anderson, Lancet 363, 453 (2004). Medline, Web of Science, Google Scholar
A. Holte and A. Mikkelsen, Maturitas 13, 193 (1991). Medline, Web of Science, Google Scholar
S. Hulley, D. Grady and T. Bush, JAMA 280, 605 (1998). Medline, Web of Science, Google Scholar
M. Hunter, R. Battersby and M. Whitehead, Maturitas 8, 217 (1986). Medline, Web of Science, Google Scholar
S. N. Indira and V. N. Murthy, J. Clin. Psychol. 7, 125 (1980). Web of Science, Google Scholar
P. A. Jacobs and M. E. Hyland, Maturitas 46, 273 (2003). Medline, Web of Science, Google Scholar
A. Kagayaet al., Neuropsychobiology 43, 59 (2001). Medline, Web of Science, Google Scholar
S. Kanbaet al., Psychiatr. Clin. Neurosci. 52, S331 (1998). Medline, Web of Science, Google Scholar
P. Kaufert and J. Syrotuik, Soc. Sci. Med. 15, 173 (1981). Google Scholar
Y. Kojima, Kampo Med. 5, 9 (1981). Web of Science, Google Scholar
F. Kronenberg and A. Fugh-Berman, Ann. Intern. Med. 137, 805 (2002). Medline, Web of Science, Google Scholar
J. H. Lerner, Altern. Ther. Health. Med. 7, 21 (2001). Medline, Web of Science, Google Scholar
S. K. Lutgendorfet al., J. Gerontol. A. Biol. Sci. Med. Sci. 54, M434 (1999). Medline, Web of Science, Google Scholar
N. Mantaniet al., Psychiatr. Clin. Neurosci. 56, 1323 (2002). Google Scholar
G. Marcozziet al., Maturitas 45, 225 (2003). Medline, Web of Science, Google Scholar
P. Marxet al., Maturitas 47, 47 (2004). Medline, Web of Science, Google Scholar
N. L. McCoy, Maturitas 29, 51 (1998). Medline, Web of Science, Google Scholar
A. Mikkelsen and A. Holte, Psychiatr. Soc. Sci. 2, 35 (1982). Google Scholar
Million Women Study Collaborators Lancet 362, 419 (2003). Medline, Web of Science, Google Scholar
A. Ponpornpisit, M. Endo and H. Murata, Fish Pathol. 36, 1 (2001). Web of Science, Google Scholar
A. Reichenberget al., Arch. Gen. Psychiatr. 58, 445 (2001). Medline, Web of Science, Google Scholar
M. A. Richardson, J. Nutr. 131(), 3037S (2001). Medline, Web of Science, Google Scholar
L. Russelet al., Am. J. Med. Sci. 324, 185 (2002). Medline, Web of Science, Google Scholar
R. Slopienet al., Maturitas 46, 255 (2003). Medline, Web of Science, Google Scholar
Q. H. Songet al., Am. J. Chin. Med. 29, 433 (2001). Link, Web of Science, Google Scholar
M. Takeishiet al., Studies on efficacy of the herbal MACH on IgE, interferon and intra-peritoneal macrophage in mice, The Proceedings of the 4th Advanced Traditional Chinese Veterinary Medicine Seminar (Chi Institute, Florida, USA, 2000) pp. 85–102. Google Scholar
Y. Talameh, R. Wei and H. Nato, Clin. Chem. Acta 158, 33 (1986). Medline, Web of Science, Google Scholar
H. J. Teede, Aust. Fam. Physician 31, 413 (2002). Medline, Google Scholar
K. Terasawa, KAMPO — Japanese Oriental Medicine (K.K. STANDARD McINTYPE, Tokyo, 1993) pp. 43–51. Google Scholar
A. B. Thomsenet al., Maturitas 47, 39 (2004). Medline, Web of Science, Google Scholar
K. Toriizukaet al., J. Ethnopharmacol. 71, 133 (2000). Medline, Web of Science, Google Scholar
H. Toriumiet al., Clinical efficacy of the feed additive MACH on the incidence of respiratory diseases in piglets, The Proceedings of Guangzhou International Conference on the Advanced Traditional Chinese Veterinary Medicine 2000 (Chi Institute, Florida, USA, 2000) pp. 193–196. Google Scholar
T. Ushiroyama, The Menopause at the Millennium, eds. T. Aso, T. Yanaihara and S. Fujimoto (Parthenon Publishing, New York, London, 2000) pp. 256–264. Google Scholar
T. Ushiroyama, A. Ikeda and M. Ueki, Int. J. Gynecol. Obstet. 79, 51 (2002). Medline, Web of Science, Google Scholar
T. Ushiroyama, A. Ikeda and M. Ueki, J. Tradit. Med. 4, 150 (2003). Web of Science, Google Scholar
H. Watanabeet al., Am. J. Chin. Med. 30, 65 (2002). Link, Web of Science, Google Scholar
N. Wiseman and A. Ellis, Fundamentals of Chinese Medicine, eds. N. Wiseman and A. Ellis (Paradigm Publications, Blookline, Massachusetts, 1996) pp. 22–23. Google Scholar
Women's Health Initiative Investigators JAMA 288, 321 (2002). Medline, Web of Science, Google Scholar
M. Yilmazeret al., Maturitas 46, 245 (2003). Medline, Web of Science, Google Scholar
M. Yoshidaet al., Study of therapeutic effect of plant complex feed C-UP III on subclinical mastitis caused by S. aureus in daily cows and activation of blood macrophages, The Proceedings of Pacific Congress on Milk Quality and Mastitis Control (Organizing Committee of the Pacific Congress on Milk Quality and Mastitis Control, Nagoya, Japan, 2000) pp. 547–552. Google Scholar
C. M. Yu, J. C. Chan and J. C. Sanderson, J. Intern. Med. 241, 337 (1997). Medline, Web of Science, Google Scholar