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Aldose Reductase Inhibitors from Viola hondoensis W. Becker et H Boss

Department of Applied Life Science, Kon Kuk University, Seoul, 143-701, South Korea

Department of Diagnostics, College of Korean Medicine and Cardiovascular Medical Research Center, Dongguk University, Gyeong-Ju 780-714, South Korea

Won-Hwan Park contributed equally to this work.

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Hyung-In Moon

Department of Neuroscience and Inam Neuroscience Research Center, Sanbon Medical Center, Wonkwang University, Gunpo-city, Kyunggido, 435-040, South Korea

Hyung-In Moon contributed equally to this work.

Correspondence: Dr. Hyung-In Moon, Department of Neuroscience and Inam Neuroscience Research Center, Sanbon Medical Center, Wonkwang University, Gunpo-city, Kyunggido, 435-040, South Korea.

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https://doi.org/10.1142/S0192415X08006247Cited by:13 (Source: Crossref)

Abstract

The isolation and characterization of rat lens aldose reductase inhibitors from the Viola hondoensis W. Becker et H Boss were conducted. The extracts and organic fractions from V. hondoensis were tested. The MeOH extract and EtOAc fraction were found to exhibit potent rat lens aldose reductase inhibition in vitro, their IC₅₀ being 1.2 and 0.6 μg/ml, respectively. One major isoflavonoid glycoside was isolated from the ethyl acetate soluble fraction of V. hondoensis. Kakkalide was found to be the potential rat lens aldose reductase inhibitor (IC₅₀ = 0.34 μg/ml), and may be useful for the prevention and/or treatment of diabetic complications.

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