Effect of Glycyrrhizin on Lysosomes Labilization by Phospholipase A₂

The influence of glycyrrhizin on the effect of phospholipase A₂ on lysosomes was studied. Treatment of rat liver lysosomes with venom phospholipase A₂ caused release of acid phosphatase. This release of acid phosphatase was inhibited by 0.1 mM glycyrrhizin. Glycyrrhizin also inhibited acid phospholiase A₂ with pH optimum of 4.5, which is thought to be present in the lysosomal membrane.

These results suggests that glycyrrhizin stabilizes lysosomes by inhibiting phospholipase A₂ activity in the lysosomal membrane.