Research ArticlesNo Access

APPLICATION OF TECHNETIUM AND RHENIUM IN NUCLEAR MEDICINE

ROGER ALBERTO

University of Zürich, Institute of Inorganic Chemistry, Winterthurerstr. 190, CH-8057 Zürich, Switzerland

https://doi.org/10.1142/S0219607712300019Cited by:15 (Source: Crossref)

Abstract

Technetium and Rhenium are the two lower elements in the manganese triad. Whereas rhenium is known as an important part of high resistance alloys, technetium is mostly known as a cumbersome product of nuclear fission. It is less known that its metastable isotope ^99mTc is of utmost importance in nuclear medicine diagnosis. The technical application of elemental rhenium is currently complemented by investigations of its isotope ¹⁸⁸Re, which could play a central role in the future for internal, targeted radiotherapy. This article will briefly describe the basic principles behind diagnostic methods with radionuclides for molecular imaging, review the ^99mTc-based radiopharmaceuticals currently in clinical routine and focus on the chemical challenges and current developments towards improved, radiolabeled compounds for diagnosis and therapy in nuclear medicine.

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References

H. R. Herschman, Science 302, 605 (2003). Crossref, Google Scholar
D. M. Shin, D. Majumdar and X. H. Peng, Curr. Top. Med. Chem. 10, 1211 (2010). Google Scholar
P. E. Kinahan and D. L. Chen, J. Magn. Reson. Imaging. 32, 1409 (2010). Google Scholar
S. L. Pimlott and A. Sutherland, Chem. Soc. Rev. 40, 149 (2011). Crossref, Google Scholar
A. J. Sinusas and L. W. Dobrucki, Nat. Rev. Cardiol. 7, 38 (2010). Google Scholar
P. Blower, J. Chem. Soc., Dalton Trans. 1705 (2006). Google Scholar
R. Alberto and U. Abram, Nuclear Chemistry 4, eds. A. Vertes, S. Nagy and Z. Klencsar (Kluwer Academic Publisher, Dordrecht, 2005) pp. 211–256. Google Scholar
M. D. Bartholomaet al., Chem. Rev. 110, 2903 (2010). Crossref, Google Scholar
S. Liu, Adv. Drug. Deliver. Rev. 60, 1347 (2008). Crossref, Google Scholar
E. Meggers, Curr. Opin. Chem. Biol. 11, 287 (2007). Crossref, Google Scholar
M. J. Abramset al., Inorg. Chem. 22, 2798 (1983). Crossref, Google Scholar
M. P. Kunget al., Eur. J. Nucl. Med. 24, 372 (1997). Google Scholar
D. Y. Chiet al., J. Med. Chem. 37, 928 (1994). Crossref, Google Scholar
R. Alberto, J. Organomet. Chem. 692, 1179 (2007). Crossref, Google Scholar
R. Alberto, Bioorganometallics, ed. G. Jaouen (Wiley-VCH, Weinheim, 2006) pp. 97–124. Crossref, Google Scholar
I. Noddack and W. Noddack, Z. Phys. Chem. 125, 264 (1927). Google Scholar
C. Perrier and E. Segre, Nature (London) 140, 193 (1937). Crossref, Google Scholar
F. F. Knappet al., Anticancer Res. 17, 1783 (1997). Google Scholar
S. Liu, Chem. Soc. Rev. 33, 445 (2004). Crossref, Google Scholar
C. Burchardtet al., Bioorg. Med. Chem. Lett. 19, 3498 (2009). Crossref, Google Scholar
C. J. Anderson and M. J. Welch, Chem. Rev. 99, 2219 (1999). Crossref, Google Scholar
H. R. Maecke and M. Eisenhut, Bioinorg. Chem. 2, 1079 (1995). Google Scholar
R. C. Mease and C. Lambert, Semin. Nucl. Med. 31, 278 (2001). Crossref, Google Scholar
S. R. Banerjeeet al., Nucl. Med. Biol. 32, 1 (2005). Crossref, Google Scholar
B. A. Nocket al., Eur. J. Nucl. Med. Mol. I. 34, 1804 (2007). Google Scholar
T. Mainaet al., Nucl. Med. Biol. 37, 708 (2010). Crossref, Google Scholar
D. Eshimaet al., J. Nucl. Med. 28, 1180 (1987). Google Scholar
D. Eshima, A. R. Fritzberg and A. Taylor, Semin. Nucl. Med. 20, 28 (1990). Crossref, Google Scholar
T. J. Hoffmanet al., J. Nucl. Med. 26, P129 (1985). Google Scholar
D. P. Nowotniket al., Nucl. Med. Commun. 6, 499 (1985). Crossref, Google Scholar
P. F. Sharpet al., J. Nucl. Med. 27, 171 (1986). Google Scholar
S. Z. Leveret al., J. Nucl. Med. 26, 1287 (1985). Google Scholar
R. C. Walovitchet al., J. Nucl. Med. 30, 1892 (1989). Google Scholar
S. Z. Lever, K. E. Baidoo and A. Mahmood, Inorg. Chim. Acta. 176, 183 (1990). Crossref, Google Scholar
R. C. Walovitchet al., J. Cerebr. Blood F. Met. 14, S4 (1994). Google Scholar
B. Johannsen and H. J. Pietzsch, Eur. J. Nucl. Med. Mol. Imaging 29, 263 (2002). Crossref, Google Scholar
M.-P. Kunget al., Eur. J. Nucl. Med. 24, 372 (1997). Google Scholar
H. F. Kunget al., Nucl. Med. Biol. 34, 787 (2007). Crossref, Google Scholar
B. E. Backuset al., J. Nucl. Cardiol. 16, 97 (2009). Crossref, Google Scholar
T. Deyet al., Eur. Heart. J. Suppl. 13, A106 (2011). Google Scholar
A. G. Joneset al., Int. J. Nucl. Med. Biol. 11, 225 (1984). Crossref, Google Scholar
K. A. Naraharaet al., Am. J. Cardiol. 66, 1438 (1990). Crossref, Google Scholar
L. Mariaet al., Dalton Trans. 3010 (2007). Google Scholar
L. Mariaet al., Dalton. T. 603 (2009). Google Scholar
Z. Heet al., Nucl. Med. Biol. 33, 1045 (2006). Crossref, Google Scholar
S. Liu, Dalton Trans. 1183 (2007). Google Scholar
P. A. Domstadet al., Radiology 136, 209 (1980). Crossref, Google Scholar
I. Carrio, C. Mari and A. Catafau, Q. J. Nucl. Med. 43, 259 (1999). Google Scholar
D. Y. Chi and J. A. Katzenellenbogen, J. Am. Chem. Soc. 115, 7045 (1993). Crossref, Google Scholar
A. Boschiet al., Nucl. Med. Commun. 23, 689 (2002). Crossref, Google Scholar
A. Boschi, A. Duatti and L. Uccelli, Top. Curr. Chem. 252, 85 (2005). Crossref, Google Scholar
C. Mulleret al., Eur. J. Nucl. Med. Mol. I. 33, 1007 (2006). Crossref, Google Scholar
M. Waltheret al., Bioconjugate Chem. 18, 216 (2007). Crossref, Google Scholar
C. L. Ferreiraet al., Bioconjug Chem. 17, 1321 (2006). Crossref, Google Scholar
R. Albertoet al., J. Am. Chem. Soc. 123, 3135 (2001). Crossref, Google Scholar
R. Albertoet al., Biopolymers 76, 324 (2004). Crossref, Google Scholar
H. Spieset al., Inorg. Chim. Acta. 240, 465 (1995). Crossref, Google Scholar
R. Pasqualiniet al., J. Nucl. Med. 35, 334 (1994). Google Scholar
C. Bolzatiet al., Eur. J. Inorg. Chem. 1902 (2004). Google Scholar
R. Pasqualini and A. Duatti, J. Chem. Soc., D.: Chem. Commun. 1354 (1992). Google Scholar
C. Bolzatiet al., Bioconjugate Chem. 15, 628 (2004). Crossref, Google Scholar
C. Bolzatiet al., J. Am. Chem. Soc. 124, 11468 (2002). Crossref, Google Scholar
C. Bolzatiet al., Bioconjugate Chem. 14, 1231 (2003). Crossref, Google Scholar
A. Boschiet al., Bioconjugate Chem. 14, 1279 (2003). Crossref, Google Scholar
A. Kordeet al., Bioorgan. Med. Chem. 14, 793 (2006). Crossref, Google Scholar
S. Agostiniet al., J. Pept. Sci. 13, 211 (2007). Crossref, Google Scholar
K. Hatadaet al., J. Nucl. Med. 45, 2095 (2004). Google Scholar
R. Alberto, Compr Coord Chem II 5, eds. J. A. Mc Cleverty and T. S. Meer (Elsevier Science, Amsterdam, 2003) pp. 127–271. Google Scholar
S. Seifertet al., Bioconjugate Chem. 15, 856 (2004). Crossref, Google Scholar
A. Drewset al., Nucl. Med. Biol. 29, 389 (2002). Crossref, Google Scholar
H. J. Pietzschet al., Bioconjugate Chem. 14, 136 (2003). Crossref, Google Scholar
S. Seifert and H. J. Pietzsch, Appl. Radiat. Isot. 64, 223 (2006). Crossref, Google Scholar
E. Schilleret al., Bioconjugate Chem. 16, 634 (2005). Crossref, Google Scholar
R. Alberto, Top. Organometal. Chem. 32, 219 (2010). Crossref, Google Scholar
R. Albertoet al., J. Am. Chem. Soc. 120, 7987 (1998). Crossref, Google Scholar
R. La Bellaet al., Bioconjugate Chem. 13, 599 (2002). Crossref, Google Scholar
B. Veerendraet al., Synth. React. Inorg. Me. 36, 481 (2006). Crossref, Google Scholar
C. J. Smithet al., Cancer Res. 63, 4082 (2003). Google Scholar
R. Waibelet al., Nat. Biotechnol. 17, 897 (1999). Crossref, Google Scholar
C. L. Ferreiraet al., Inorg. Chem. 45, 8414 (2006). Crossref, Google Scholar
C. L. Ferreiraet al., Inorg. Chem. 45, 6979 (2006). Crossref, Google Scholar
R. Schibliet al., Bioconjugate Chem. 16, 105 (2005). Crossref, Google Scholar
J. Bernardet al., Inorg. Chem. 42, 1014 (2003). Crossref, Google Scholar
Y. Liuet al., J. Am. Chem. Soc. 128, 15996 (2006). Crossref, Google Scholar
H. W. P. N'Dongoet al., Nucl. Med. Biol. 37, 255 (2010). Crossref, Google Scholar
R. F. Vitoret al., ChemBioChem 9, 131 (2008). Crossref, Google Scholar
R. Alberto, Eur. J. Nucl. Med. Mol. I. 30, 1299 (2003). Crossref, Google Scholar
M. Welch, Eur. J. Nucl. Med. Mol. Imaging. 30, 1302 (2003). Crossref, Google Scholar
R. Garciaet al., J. Am. Chem. Soc. 122, 11240 (2000). Crossref, Google Scholar
J. F. Valliantet al., Inorg. Chem. 41, 2731 (2002). Crossref, Google Scholar
A. E. C. Green, L. E. Harrington and J. F. Valliant, Can. J. Chem. 86, 1063 (2008). Crossref, Google Scholar
A. E. C. Green, S. K. Parker and J. F. Valliant, J. Organomet. Chem. 694, 1736 (2009). Crossref, Google Scholar
J. Waldet al., Angew. Chem., Int. Ed. 40, 3062 (2001). Crossref, Google Scholar
Y. Liuet al., J. Am. Chem. Soc. 130, 1554 (2008). Crossref, Google Scholar
R. Albertoet al., Org. Biomol. Chem. 8, 2829 (2010). Google Scholar
S. H. Park, S. Seifert and H. J. Pietzsch, Bioconjugate Chem. 17, 223 (2006). Crossref, Google Scholar
A. Louie, Chem. Rev. 110, 3146 (2010). Crossref, Google Scholar
S. Satoet al., Inorg. Chem. 46, 3531 (2007). Crossref, Google Scholar
B. Probstet al., Inorg. Chem. 50, 3404 (2011). Crossref, Google Scholar
M. Bartholomaet al., Chem. Commun. 493 (2009). Google Scholar
P. Haefligeret al., Bioconjugate Chem. 16, 582 (2005). Crossref, Google Scholar
K. A. Stephensonet al., Bioconjugate Chem. 15, 128 (2004). Crossref, Google Scholar
K. A. Stephensonet al., J. Am. Chem. Soc. 126, 8598 (2004). Crossref, Google Scholar
P. J. A. G. Schafferet al., Nucl. Med. Biol. 35, 159 (2008). Crossref, Google Scholar
K. A. Stephensonet al., Bioconjugate Chem. 19, 1087 (2008). Crossref, Google Scholar
N. Viola-Villegaset al., J. Med. Chem. 52, 5253 (2009). Crossref, Google Scholar
C. A. Puckett, R. J. Ernst and J. K. Barton, Dalton. T. 39, 1159 (2010). Crossref, Google Scholar
J. K. Barton and C. A. Puckett, Bioorgan. Med. Chem. 18, 3564 (2010). Google Scholar
J. K. Barton and C. A. Puckett, Biochemistry-Us 47, 11711 (2008). Google Scholar
M. P. Coogan and F. L. Thorp-Greenwood, Dalton. T. 40, 6129 (2011). Google Scholar
M. P. Coogan, V. Fernandez-Moreira and F. L. Thorp-Greenwood, Chem. Commun. 46, 186 (2010). Google Scholar
A. A. S. Tavares and J. M. R. S. Tavares, Int. J. Radiat. Biol. 86, 261 (2010). Crossref, Google Scholar
J. A. O'Donoghue and T. E. Wheldon, Phys. Med. Biol. 41, 1973 (1996). Crossref, Google Scholar
P. Häfligeret al., ChemBioChem 6, 414 (2005). Crossref, Google Scholar
N. Agorastoset al., Chem. Eur. J. 13, 3842 (2007). Crossref, Google Scholar
K. Zelenka, L. Borsig and R. Alberto, Bioconjugate Chem. 22, 958 (2011). Crossref, Google Scholar
K. Zelenka, L. Borsig and R. Alberto, Org. Biomol. Chem. 9, 1071 (2011). Crossref, Google Scholar
S. Topet al., J. Am. Chem. Soc. 117, 8372 (1995). Crossref, Google Scholar
G. Jaouenet al., Chem. Commun. 383 (2001). Google Scholar
G. Jaouen, Chem. Brit. 37, 36 (2001). Google Scholar
G. Jaouen (ed.) , Bioorganometallics: Biomolecules, Labeling, Medicine ( Wiley-VCH , Weinheim , 2005 ) . Crossref, Google Scholar
M. Wenzel and C. Klinge, J. Labelled. Compd. Radiopharm. 34, 981 (1994). Crossref, Google Scholar
R. R. Cesatiet al., J. Labelled. Compd. Radiopharm. 42, S150 (1999). Google Scholar
R. K. Hom and J. A. Katzenellenbogen, Nucl. Med. Biol. 24, 485 (1997). Crossref, Google Scholar
H. W. P. N'Dongoet al., J. Organomet. Chem. 694, 981 (2009). Crossref, Google Scholar