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From studies on artemisinin derivatives to trioxaquines

Bernard Meunier

Laboratoire de Chimie de Coordination du CNRS, 205 route de Narbonne, 31077 Toulouse cedex 4, France

Corresponding author.

https://doi.org/10.1142/S1088424602000312Cited by:4 (Source: Crossref)

Abstract

Heme, resulting from hemoglobin digestion by the malaria parasite is one of the main target of antimalarial drugs like chloroquine and artemisinin. This later molecule contains a trioxane which is activated by the reduced form of heme to generate a strong alkylating agent able to react with heme itself. Taking advantage of these studies, we prepared new antimalarial drugs, trioxaquines, containing a trioxane motif covalently linked to an aminoquinoline.

Keywords:

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