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Cationic tetrapyrrolic macromolecules as new acetylcholinesterase inhibitors

Tian Tian

College of Chemistry and Molecular Sciences, Wuhan University, Hubei, Wuhan 430072, PR China

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Liwei Weng

College of Chemistry and Molecular Sciences, Wuhan University, Hubei, Wuhan 430072, PR China

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Shaoru Wang

College of Chemistry and Molecular Sciences, Wuhan University, Hubei, Wuhan 430072, PR China

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Xiaocheng Weng

College of Chemistry and Molecular Sciences, Wuhan University, Hubei, Wuhan 430072, PR China

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Lixia Zhang

College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, PR China

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, and

Xiang Zhou

College of Chemistry and Molecular Sciences, Wuhan University, Hubei, Wuhan 430072, PR China

Corresponding author, tel: +86 27-61056559, fax: +86 27-87336380.

SPP full member in good standing.

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https://doi.org/10.1142/S1088424609001169Cited by:17 (Source: Crossref)

Abstract

A series of tetrapyrrolic macrocycles such as porphyrins, phthalocyanines and corroles were found to have inhibitory abilities toward acetylcholinesterase (AChE). Their structure-activity relationship was studied. Several compounds were found to have good inhibitory abilities, which could be developed as potential candidates of acetylcholinesterase (AchE) inhibitors.

Keywords:

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