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Synthetic porphyrins bearing β-propionate chains as photosensitizers for photodynamic therapy

Nelson Pereira

Chymiotechnon, Departamento de Química, Universidade de Coimbra, 3004-535 Coimbra, Portugal

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Arménio C. Serra

Chymiotechnon, Departamento de Química, Universidade de Coimbra, 3004-535 Coimbra, Portugal

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Marta Pineiro

Chymiotechnon, Departamento de Química, Universidade de Coimbra, 3004-535 Coimbra, Portugal

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António M. d'A. Rocha Gonsalves

Chymiotechnon, Departamento de Química, Universidade de Coimbra, 3004-535 Coimbra, Portugal

Centro de Investigação em Ambiente, Genética e Oncobiologia, (CIMAGO), Faculdade de Medicina de Coimbra, 3000-354 Coimbra, Portugal

Corresponding author, tel: +351 239-854-479, fax: +351 239-826-068.

SPP full member in good standing.

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Margarida Abrantes

Instituto de Biofísica/Biomatemática, IBILI, Faculdade de Medicina de Coimbra, 3000-354 Coimbra, Portugal

Centro de Investigação em Ambiente, Genética e Oncobiologia, (CIMAGO), Faculdade de Medicina de Coimbra, 3000-354 Coimbra, Portugal

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Mafalda Laranjo

Instituto de Biofísica/Biomatemática, IBILI, Faculdade de Medicina de Coimbra, 3000-354 Coimbra, Portugal

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Filomena Botelho

Instituto de Biofísica/Biomatemática, IBILI, Faculdade de Medicina de Coimbra, 3000-354 Coimbra, Portugal

Centro de Investigação em Ambiente, Genética e Oncobiologia, (CIMAGO), Faculdade de Medicina de Coimbra, 3000-354 Coimbra, Portugal

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https://doi.org/10.1142/S1088424610002227Cited by:12 (Source: Crossref)

Abstract

Porphyrins with different numbers of β-propionate chains mimicking natural porphyrins were prepared via the 2+2 MacDonald type approach. Photodynamic activity against WiDr colon adenocarcinoma cells showed that activity is related to the number of β-propionate chains, with the derivatives with two carboxylic groups showing higher activity.

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