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The synthesis of new potential photosensitizers [1–3]. Part 4. Photophysical properties of some monophenyltripyridyl-porphyrin derivatives

Piotr Kuś

Department of Chemistry, University of Silesia, 9, Szkolna Street, 40-006 Katowice, Poland

E-mail Address: pkus@ich.us.edu.pl

Corresponding author.

SPP full member in good standing.

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Anna Pasewicz-Sokół

A. Chełkowski Institute of Physics, University of Silesia, 4, Uniwersytecka Street, 40-007 Katowice, Poland

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Alicja Ratuszna

A. Chełkowski Institute of Physics, University of Silesia, 4, Uniwersytecka Street, 40-007 Katowice, Poland

Silesian Center for Education and Interdisciplinary Research, 75 Pułku Piechoty 1A, 41-500 Chorzów, Poland

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, and

Marcin Rojkiewicz

Department of Chemistry, University of Silesia, 9, Szkolna Street, 40-006 Katowice, Poland

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https://doi.org/10.1142/S1088424615501047Cited by:1 (Source: Crossref)

Abstract

Six monophenyltripyridylporphyrin derivatives were synthesized and characterized by spectroscopy in order to demonstrate their potential usefulness as photosensitizers for anticancer therapy purposes. Compounds 1 and 3–5 are amphiphilic, thus they may be suitable for transfer inside cells. Photochemical parameters such as fluorescence yield and singlet oxygen yield were determined. The former parameter does not exceed 10% which makes them unsuitable for photodynamic diagnosis (PDD). However, singlet oxygen yields are high and sufficient for these compounds to be considered as potential photodynamic therapy (PDT) photosensitizers.

Keywords:

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