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Tamoxifen-zinc(II) phthalocyanine conjugates for target-based photodynamic therapy and hormone therapy

College of Pharmaceutical Science, Zhejiang Chinese Medical University, 548 Binwen Road, Hangzhou, 310053, P. R. China

The Second People’s Hospital Affiliated to Fujian University of Traditional Chinese Medicine, 282 Wusi Road, Fuzhou 350003, Fujian, P. R. China

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Hui-Lan Weng

The Second People’s Hospital Affiliated to Fujian University of Traditional Chinese Medicine, 282 Wusi Road, Fuzhou 350003, Fujian, P. R. China

E-mail Address: WHL801@sina.com

Correspondence to: Hui-Lan Weng, tel.: +86 591 8782 5344, fax: +86 591 8782 5344

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, and

Jin-Ping Xue

National & Local Joint Biomedical Engineering Research Center on Photodynamic Technologies, and Fujian Engineering Research Center for Drug and Diagnoses and Treatment of Photodynamic Therapy, College of Chemistry, Fuzhou University, Fuzhou, Fujian 350116, P. R. China

E-mail Address: xuejinping66@fzu.edu.cn

Correspondence to: Jin-Ping Xue, tel.: +86 591 2286 7923, fax: +86 591 2286 7963

SPP full member in good standing.

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https://doi.org/10.1142/S108842461950161XCited by:4 (Source: Crossref)

Abstract

Although photodynamic therapy has been extensively studied in recent years and preclinical studies have shown promising results, strategies for enhancing PDT outcomes and reducing side effects still urgently need to be developed. In this study, a series of Tamoxifen-zinc(II) phthalocyanine conjugates have been designed and synthesized. In these “double-headed” conjugates, photodynamic therapy agent zinc(II) phthalocyanine and hormone therapy drug Tamoxifen were combined via oligoethylene glycol linkers. The conjugates show high specificity, and some of them show cytotoxic effects against the MCF-7 cells overexpressed Estrogen receptor, due to the targeting and cytostatic Tamoxifen moiety. Upon illumination, all these conjugates show high cytotoxicity due to the photosensitizing phthalocyanine unit. Their structure-activity relationship was also assessed. The results show that $α$ -substituted Tamoxifen-zinc(II) phthalocyanine conjugates are highly promising anticancer targeting agents which exhibit additive effects of photodynamic therapy and hormone therapy.

Keywords:

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