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Stabilities of Irradiated DNA Complexes from Sarcoma 45 Tumors with Mitoxantrone at Small Fillings

Sergey N. Hakobyan

Department of Mechanical Engineering, State Engineering University of Armenia, 105 Teryan St., Yerevan 0009, Armenia

E-mail Address: 1977poi@gmail.com

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Mariam A. Shahinyan

Department of Biophysics, Faculty of Biology, Yerevan State University, 1 Alex Manoogian St. Yerevan 0025, Armenia

E-mail Address: m.shahinyan@ysu.am

Corresponding author.

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Yuri S. Babayan

Department of Physics and Electrochemicals, National University of Architecture and Construction of Armenia, 105 Teryan St., Yerevan 0009, Armenia

E-mail Address: babayanyura@gmail.com

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https://doi.org/10.1142/S1793048016500028Cited by:6 (Source: Crossref)

Abstract

In the present work, the thermostabilities of mitoxantrone (MTX) complexes with DNA from sarcoma 45 and healthy rat liver were studied. DNAs from both sources were irradiated by resonant (64.5 GHz and 50.3 GHz) and nonresonant (48.3 GHz) frequencies of water. The obtained data showed that DNA solution irradiation by resonant frequencies of water induces a dehydration of nucleotides and Na $^{+}$ ions in the solution. It is shown that at relatively low concentrations of MTX, when one MTX molecule binds to almost 100 pairs of bases of DNA, the thermostabilities of complexes decrease. Moreover, this change is more pronounced ( $\sim 0 . 8^{\circ}$ C) at the complex formation with DNA released from sarcoma 45 tumor.

Keywords:

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