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FABRICATION OF NANOPOROUS CHITOSAN MEMBRANES

Department of Mechanical Engineering, University College London, Torrington Place, London WC1E 7JE, UK

National Engineering Research Centre for Biomaterials, Sichuan University, Chengdu 610064, P. R. China

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Department of Mechanical Engineering, University College London, Torrington Place, London WC1E 7JE, UK

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Department of Mechanical Engineering, University College London, Torrington Place, London WC1E 7JE, UK

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MOHAN EDIRISINGHE

Department of Mechanical Engineering, University College London, Torrington Place, London WC1E 7JE, UK

Corresponding author.

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https://doi.org/10.1142/S1793292010001846Cited by:2 (Source: Crossref)

Abstract

Naturally derived biopolymers have been widely used for biomedical applications such as drug carriers, wound dressings, and tissue engineering scaffolds. Chitosan is a typical polysaccharide of great interest due to its biocompatibility and film-formability. Chitosan membranes with controllable porous structures also have significant potential in membrane chromatography. Thus, the processing of membranes with porous nanoscale structures is of great importance, but it is also challenging and this has limited the application of these membranes to date. In this study, with the aid of a carefully selected surfactant, polyethyleneglycol stearate-40, chitosan membranes with a well controlled nanoscale structure were successfully prepared. Additional control over the membrane structure was obtained by exposing the suspension to high intensity, low frequency ultrasound. It was found that the concentration of chitosan/surfactant ratio and the ultrasound exposure conditions affect the structural features of the membranes. The stability of nanopores in the membrane was improved by intensive ultrasonication. Furthermore, the stability of the blended suspensions and the intermolecular interactions between chitosan and the surfactant were investigated using scanning electron microscope and Fourier transform infrared spectroscopy (FTIR) analysis, respectively. Hydrogen bonds and possible reaction sites for molecular interactions in the two polymers were also confirmed by FTIR analysis.

Keywords:

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Vol. 05, No. 01

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History

Received 13 October 2009

Revised 17 November 2009

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