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One-Step Fabrication of Fluorescent Carbon Dots for Selective and Sensitive Detection of Cr (VI) in Living Cells

JiLin Electric Power Company Limited Electric Power, Research Institute Changchun 130021, P. R. China

Lab of Polymer Composites Engineering, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China

E-mail Address: ynjiang@ciac.ac.cn

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Chuanxi Wang

China-Australia Joint Research Centre, for Functional Molecular Materials, School of Chemical & Material Engineering, Jiangnan University, Wuxi 214122, P. R. China

E-mail Address: wangcx@jiangnan.edu.cn

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https://doi.org/10.1142/S1793292016500120Cited by:11 (Source: Crossref)

Abstract

A one-step facile method of synthesizing fluorescent carbon dots (CDs) has been demonstrated, whereby fluorescent CDs are produced through hydrothermal treatment of glucose in the presence of H₃BO₃ with a fluorescence quantum yield of 14.5%. It is found that spherical CDs have an average size of 3.7nm as well as good monodispersion in aqueous solution. The added Cr (VI) selectively leads to the inner filter effect (IFE)-based fluorescence quenching of the CDs. Such fluorescence responses can be used for well quantifying Cr (VI) in the range of 0.05–200 $μ$ $μ$ M. Significantly, the CDs possess negligible cytotoxicity, excellent biocompatibility and high selectivity. All these features are favorable for label-free monitoring of Cr (VI) in complex biological samples. It was then successfully applied for the fluorescence imaging of intracellular Cr (VI). As an efficient chemosensor, the CDs hold great promise in broadening their applications in biological systems.

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