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The Detection of Osthole and Application of Cell Imaging Based on Nitrogen-Doped Carbon Dots

Ning Wang

School of Basic Medical Science, Shanxi Medical University, Taiyuan 030001, P. R. China

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Xuefang Yang

School of Basic Medical Science, Shanxi Medical University, Taiyuan 030001, P. R. China

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Haojiang Wang

School of Basic Medical Science, Shanxi Medical University, Taiyuan 030001, P. R. China

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Liping Xie

General Hospital of Tisco, Sixth Hospital of Shanxi Medical University, Taiyuan 030001, P. R. China

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Weihua Jia

General Hospital of Tisco, Sixth Hospital of Shanxi Medical University, Taiyuan 030001, P. R. China

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Wei Bian

http://orcid.org/0000-0002-7898-9571

School of Basic Medical Science, Shanxi Medical University, Taiyuan 030001, P. R. China

E-mail Address: sxykdx_bianwei@163.com

Corresponding author.

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, and

Martin M. F. Choi

Bristol Chinese Christian Church, C/O Tyndale Baptist Church, 137–139 Whiteladies Road, Bristol BS8 2QG, UK

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https://doi.org/10.1142/S1793292020500253Cited by:4 (Source: Crossref)

Abstract

A fluorescence probe has been synthesized for the detection of osthole using the nitrogen-doped carbon dots (NCDs) as shown in Fig. 1. The NCDs were fully characterized by transmission electron microscopy (TEM), X-ray diffraction (XRD), x-ray photoelectron spectroscopy (XPS), Fourier transform infrared spectroscopy (FTIR). Under the optimal experimental conditions, the NCDs fluorescence probe was highly selective and sensitive to osthole. The linear response range for osthole was 5.0–75 $μ$ $μ$ M with a detection limit of 38nM. The mechanism of the interaction of osthole and NCDs was discussed. The fluorescence probe has been applied to the analysis of biological samples. The as-synthesized NCDs with high fluorescence intensity, low toxicity and good biocompatibility were applied to cell imaging.

Keywords:

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