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Sensitive and Specific Detecting Biomarker of Radiation-Resistant Nasopharyngeal Carcinoma by TpTta-COF Nanosheet

Zhaoyu Han

School of Pharmaceutical Sciences, Jiangnan University, Wuxi 214122, P. R. China

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Sen Li

School of Pharmaceutical Sciences, Jiangnan University, Wuxi 214122, P. R. China

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Shaoxian Yin

School of Pharmaceutical Sciences, Jiangnan University, Wuxi 214122, P. R. China

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Yanfei Cai

School of Pharmaceutical Sciences, Jiangnan University, Wuxi 214122, P. R. China

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Jian Jin

School of Pharmaceutical Sciences, Jiangnan University, Wuxi 214122, P. R. China

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Gang Huang

Shanghai Key Laboratory of Molecular Imaging, Shanghai University of Medicine and Health Sciences, Shanghai 201318, P. R. China

E-mail Address: huanggang@sumhs.edu.cn

Corresponding author.

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, and

Zhaoqi Yang

School of Pharmaceutical Sciences, Jiangnan University, Wuxi 214122, P. R. China

E-mail Address: zhaoqiyang@jiangnan.edu.cn

Corresponding author.

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https://doi.org/10.1142/S1793292021500697Cited by:1 (Source: Crossref)

Abstract

An important attribute of microRNA-205 (MiR-205) is their potential use as predictive biomarker for anti-radiation of nasopharyngeal carcinoma (NPC), and it is pivotal to monitor the dynamic change of MiR-205 for personalized precise treatment strategies. So far, there are several methods aiming at detecting MiR-205 while rarely has worked out questions such as limited complex detection processes, poor sample detection limit or spending lots of time. Therefore, a method for detecting MiR-205 based on 2D COF nanosheets and fluorescent oligonucleotide probe was constructed and investigated in this study. The 2D COF nanosheet quenches the fluorescence of the fluorescent single-stranded DNA (ss-DNA) probes through fluorescence resonance energy transfer (FRET). The method enables to capture MiR-205 sensitively in aqueous solution with a detection limit of 4.78nM in the range 0–500nM and $R^{2} = 0.989$ $R^{2} = 0.989$ , and the method offers great specificity in that it can distinguish the target miRNA from mismatch nontarget miRNAs. Considering its simple operability and excellent specificity, it has great application prospects in the detection of miRNA biomarker in clinical diagnosis and personalized treatment plan.

Keywords:

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