Review ArticlesOpen Access

Applications of fluorescence lifetime imaging in clinical medicine

Zhanwen Wang

Shenzhen University Health Science Center, Shenzhen 518060, P. R. China

Z. Wang and Y. Zheng contributed equally to this work and are considered as co-first authors.

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Yanping Zheng

Shenzhen University Health Science Center, Shenzhen 518060, P. R. China

Z. Wang and Y. Zheng contributed equally to this work and are considered as co-first authors.

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Deqiang Zhao

Department of Neurology, Nanfang Hospital of Southern Medical University, Guangzhou, Guangdong 510515, P. R. China

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Ziwei Zhao

Shenzhen University Health Science Center, Shenzhen 518060, P. R. China

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Lixin Liu

School of Physics and Optoelectronic Engineering, Xidian University, Xi’an 710071, P. R. China

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Artem Pliss

Institutue for Laser, Photonics and Biophotonics, State University of New York, Buffalo, New York, USA

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Feiqi Zhu

Cognitive Impairment Ward of Neurology Department, The 3rd Affiliated Hospital of Shenzhen University, Shenzhen 518001, P. R. China

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Jun Liu

Department of Neurodegenerative Diseases and Aging, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangdong, P. R. China

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Junle Qu

Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, Shenzhen University, Shenzhen 518060, P. R. China

E-mail Address: qujunle@szu.edu.cn

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, and

Ping Luan

Shenzhen University Health Science Center, Shenzhen 518060, P. R. China

Cognitive Impairment Ward of Neurology Department, The 3rd Affiliated Hospital of Shenzhen University, Shenzhen 518001, P. R. China

E-mail Address: luanping@szu.edu.cn

Corresponding author.

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https://doi.org/10.1142/S179354581830001XCited by:34 (Source: Crossref)

Abstract

Fluorescence lifetime is not only associated with the molecular structure of fluorophores, but also strongly depends on the environment around them, which allows fluorescence lifetime imaging microscopy (FLIM) to be used as a tool for precise measurement of the cell or tissue microenvironment. This review introduces the basic principle of fluorescence lifetime imaging technology and its application in clinical medicine, including research and diagnosis of diseases in skin, brain, eyes, mouth, bone, blood vessels and cavity organs, and drug evaluation. As a noninvasive, nontoxic and nonionizing radiation technique, FLIM demonstrates excellent performance with high sensitivity and specificity, which allows to determine precise position of the lesion and, thus, has good potential for application in biomedical research and clinical diagnosis.

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Vol. 11, No. 01

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Received 8 June 2017

Accepted 21 July 2017

Published: 22 August 2017

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This is an Open Access article published by World Scientific Publishing Company. It is distributed under the terms of the Creative Commons Attribution 4.0 (CC-BY) License. Further distribution of this work is permitted, provided the original work is properly cited.

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Applications of fluorescence lifetime imaging in clinical medicine

Abstract

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System Upgrade on Tue, May 28th, 2024 at 2am (EDT)

Applications of fluorescence lifetime imaging in clinical medicine

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