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DIFFERENCES IN CYTOCOMPATIBILITY BETWEEN MWCNTs AND CARBOXYLIC FUNCTIONALIZED MWCNTs

YITENG ZHANG

College of Physics and Electronic Information Science, Tianjin Normal University, Tianjin 300074, P. R. China

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DEJUN LI

College of Physics and Electronic Information Science, Tianjin Normal University, Tianjin 300074, P. R. China

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MENGLI ZHAO

College of Physics and Electronic Information Science, Tianjin Normal University, Tianjin 300074, P. R. China

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MEIXIAN GUO

College of Physics and Electronic Information Science, Tianjin Normal University, Tianjin 300074, P. R. China

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XIANGYUN DENG

College of Physics and Electronic Information Science, Tianjin Normal University, Tianjin 300074, P. R. China

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HANQING GU

Tianjin Institute of Urological Surgery, Tianjin Medical University, Tianjin 300070, Ninth People's Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai 200011, P. R. China

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, and

RONGXIN WAN

Tianjin Institute of Urological Surgery, Tianjin Medical University, Tianjin 300070, Ninth People's Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai 200011, P. R. China

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https://doi.org/10.1142/S1793604712500531Cited by:6 (Source: Crossref)

Abstract

Influence of carboxylic functionalization on the cytocompatibility of multiwalled carbon nanotubes (MWCNTs) was investigated in this work. Water contact angle assay showed that the surface of MWCNTs-containing carboxyl (MWCNTs-COOH) became much more hydrophilic compared with pure MWCNTs. In cell-adhesion assays, two cell lines, mouse fibroblast cells (L929) and human umbilical vein endothelial cells (EAHY926) were used to assess the cytocompatibility of materials. The MWCNTs-COOH displayed the improved cell proliferation, viability and adhesion due to the enhanced wettability, indicating their superior cytocompatibility over MWCNTs. The existence of carboxyl groups should be benefit to the adhesion and growth of both cells, which implied that MWCNTs-COOH were helpful for seeding both cells and could be used as the functional surface for the adhesion and growth of cells.

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