Special Issue: Selected Papers from the Fourth International Symposium on Functional Materials (ISFM 2011); Guest Editors: Prof. Tsugio Sato, Prof. Shun-Ichiro Tanaka, Prof. Dongfeng Xue, Assoc. Prof. Tohru Sekino and Assoc. Prof. Shu Yin — Research ArticlesNo Access

CELLULAR UPTAKE BEHAVIOR OF FLUORESCEIN: INTERCALATED LAYERED DOUBLE HYDROXIDE

MIYUKI TANAKA

Institute of Multidisciplinary Research for Advanced Materials, Tohoku University, 2-1-1, Katahira, Aoba-ku, Sendai 980-8577, Japan

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SUMIO AISAWA

Graduate School of Engineering, Iwate University, Morioka 020-8551, Japan

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HIDETOSHI HIRAHARA

Graduate School of Engineering, Iwate University, Morioka 020-8551, Japan

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EIICHI NARITA

Graduate School of Engineering, Iwate University, Morioka 020-8551, Japan

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SHU YIN

Institute of Multidisciplinary Research for Advanced Materials, Tohoku University, 2-1-1, Katahira, Aoba-ku, Sendai 980-8577, Japan

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, and

TSUGIO SATO

Institute of Multidisciplinary Research for Advanced Materials, Tohoku University, 2-1-1, Katahira, Aoba-ku, Sendai 980-8577, Japan

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https://doi.org/10.1142/S179360471260003XCited by:4 (Source: Crossref)

Abstract

In order to define the ability of layered double hydroxide (LDH) as materials for drug delivery, fluorescein (Fluo) anion intercalated LDH (Fluo/LDH) was synthesized by hydrothermal treatment and observed the cellular uptake of the Fluo/LDH for mammalian cell (L929). The synthesized Fluo/LDH showed a LDH structure, high fluorescence and low cytotoxicity. According to the fluorescence, confocal and TEM images of cells, the Fluo/LDH seemed to be internalized into the L929 cell by cellular endocytosis and dissolved inside the cell to exhibit the fluorescence of cellular cytoplasm.

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