Special Issue on Nanoscale Materials: Fundamentals and Applications; Guest Editors: Padma Rajagopalan and Joseph Freeman — Research ArticlesNo Access

ENDOCYTOSIS PATHWAYS FOR NUCLEIC ACID THERAPEUTICS

AMANDA P. MALEFYT

Department of Chemical Engineering and Materials Science, Michigan State University, East Lansing, Michigan 48824, USA

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S. PATRICK WALTON

Department of Chemical Engineering and Materials Science, Michigan State University, East Lansing, Michigan 48824, USA

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, and

CHRISTINA CHAN

Department of Chemical Engineering and Materials Science, Michigan State University, East Lansing, Michigan 48824, USA

Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan 48824, USA

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https://doi.org/10.1142/S179398441241005XCited by:9 (Source: Crossref)

Abstract

The development of nanoscale delivery vehicles for siRNAs is a current topic of considerable importance. However, little is understood about the exact trafficking mechanisms for siRNA-vehicle complexes across the plasma membrane and into the cytoplasm. While some information can be gleaned from studies on delivery of plasmid DNA, the different delivery requirements for these two vehicles makes drawing specific conclusions a challenge. However, using chemical inhibitors of different endocytosis pathways, studies on which endocytotic pathways are advantageous and deleterious for the delivery of nucleic acid drugs are emerging. Using this information as a guide, it is expected that the future development of effective siRNA delivery vehicles and therapeutics will be greatly improved.

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