Review ArticlesNo Access

RECAPITULATING THE VASCULAR MICROENVIRONMENT IN MICROFLUIDIC PLATFORMS

Department of Chemical and Biomolecular Engineering, Johns Hopkins Physical Sciences — Oncology Center and the Institute for NanoBioTechnology, Johns Hopkins University, 3400 N Charles St., Baltimore, MD 21218, USA

Search for more papers by this author

GERMAN DRAZER

Department of Mechanical and Aerospace Engineering, Rutgers, The State University of New Jersey, 98 Brett Rd, Piscataway, NJ 08854, USA

Corresponding authors.

Search for more papers by this author

, and

SHARON GERECHT

Corresponding authors.

Search for more papers by this author

https://doi.org/10.1142/S1793984413400011Cited by:14 (Source: Crossref)

Abstract

The vasculature is regulated by various chemical and mechanical factors. Reproducing these factors in vitro is crucial for the understanding of the mechanisms underlying vascular diseases and the development of new therapeutics and delivery techniques. Microfluidic technology offers opportunities to precisely control the level, duration and extent of various cues, providing unprecedented capabilities to recapitulate the vascular microenvironment. In the first part of this article, we review existing microfluidic technology that is capable of controlling both chemical and mechanical factors regulating the vascular microenvironment. In particular, we focus on micro-systems developed for controlling key parameters such as oxygen tension, co-culture, shear stress, cyclic stretch and flow patterns. In the second part of this article, we highlight recent advances that resulted from the use of these microfluidic devices for vascular research.

Keywords:

References

W. C. Aird , Circ. Res. 100 , 174 ( 2007 ) . Crossref, Google Scholar
N. T. Luu et al. , J. Vasc. Res. 47 , 451 ( 2010 ) . Crossref, Google Scholar
M. Liu et al. , Am. J. Pathol. 172 , 1088 ( 2008 ) . Crossref, Google Scholar
H. E. Abaci et al. , Am. J. Physiol. Cell. Physiol. 298 , C1527 ( 2010 ) . Crossref, Google Scholar
H. E. Abaci et al. , Am. J. Physiol. Cell. Physiol. 301 , C431 ( 2011 ) . Crossref, Google Scholar
G. A. Truskey , Int. J. High Throughput Screen 171 ( 2010 ) . Crossref, Google Scholar
H. E. Abaci et al. , Biomed. Microdev. 14 , 145 ( 2012 ) . Crossref, Google Scholar
E. W. Young and D. J. Beebe , Chem. Soc. Rev. 39 , 1036 ( 2010 ) . Crossref, Google Scholar
N. K. Inamdar , L. G. Griffith and J. T. Borenstein , Biomicrofluidics 5 , 22213 ( 2011 ) . Crossref, Google Scholar
R. N. Pittman , Acta. Physiol. (Oxf) 202 , 311 ( 2011 ) . Crossref, Google Scholar
P. Fraisl et al. , Dev. Cell. 16 , 167 ( 2009 ) . Crossref, Google Scholar
W. D. Ito et al. , Am. J. Physiol. 273 , H1255 ( 1997 ) . Google Scholar
D. Scholz et al. , J. Mol. Cell. Cardiol. 34 , 775 ( 2002 ) . Crossref, Google Scholar
B. S. Sorg et al. , J. Biomed. Opt. 13 , 014026 ( 2008 ) . Crossref, Google Scholar
B. J. Kane et al. , Anal. Chem. 78 , 4291 ( 2006 ) . Crossref, Google Scholar
R. H. Lam , M. C. Kim and T. Thorsen , Anal. Chem. 81 , 5918 ( 2009 ) . Crossref, Google Scholar
M. Adler et al. , Lab. Chip. 10 , 388 ( 2010 ) . Crossref, Google Scholar
J. M. Higgins et al. , Proc. Natl. Acad. Sci. USA 104 , 20496 ( 2007 ) . Crossref, Google Scholar
E. Figallo et al. , Lab. Chip. 7 , 710 ( 2007 ) . Crossref, Google Scholar
H. E. Abaci et al. , Biotechnol. Appl. Biochem. 59 , 97 ( 2012 ) . Crossref, Google Scholar
K. H. Wong et al. , Ann. Rev. Biomed. Eng. 14 , 205 ( 2012 ) . Crossref, Google Scholar
S. Chung et al. , Lab. Chip. 9 , 269 ( 2009 ) . Crossref, Google Scholar
D. Huh et al. , Science 328 , 1662 ( 2010 ) . Crossref, Google Scholar
W. Tan and T. A. Desai , J. Biomed. Mater. Res. A 72 , 146 ( 2005 ) . Crossref, Google Scholar
Y. Zheng et al. , Proc. Natl. Acad. Sci. USA 109 , 9342 ( 2012 ) . Crossref, Google Scholar
K. H. Lee et al. , Small 5 , 1264 ( 2009 ) . Crossref, Google Scholar
G. Dai et al. , Proc. Natl. Acad. Sci. USA 101 , 14871 ( 2004 ) . Crossref, Google Scholar
C. A. Reinhart-King , K. Fujiwara and B. C. Berk , Methods Enzymol. 443 , 25 ( 2008 ) . Crossref, Google Scholar
J. J. Chiu and S. Chien , Physiol. Rev. 91 , 327 ( 2011 ) . Crossref, Google Scholar
C. Hahn and M. A. Schwartz , Nat. Rev. Mol. Cell. Biol. 10 , 53 ( 2009 ) . Crossref, Google Scholar
G. Garcia-Cardena et al. , Proc. Natl. Acad. Sci. USA 98 , 4478 ( 2001 ) . Crossref, Google Scholar
S. Dimmeler et al. , Arterioscler Thromb. Vasc. Biol. 19 , 656 ( 1999 ) . Crossref, Google Scholar
R. J. Dekker et al. , Blood 100 , 1689 ( 2002 ) . Crossref, Google Scholar
E. Tzima et al. , Nature 437 , 426 ( 2005 ) . Crossref, Google Scholar
E. Tkachenko et al. , Lab. Chip. 9 , 1085 ( 2009 ) . Crossref, Google Scholar
P. L. Voyvodic , D. Min and A. B. Baker , Lab. Chip. 12 , 3322 ( 2012 ) . Crossref, Google Scholar
A. D. van der Meer et al. , Biomicrofluidics 4 , 11103 ( 2010 ) . Crossref, Google Scholar
P. Lee et al. , Biomed. Microdev. 8 , 35 ( 2006 ) . Crossref, Google Scholar
B. L. Gray et al. , Biomed. Microdev. 4 , 9 ( 2002 ) . Crossref, Google Scholar
G. Mehta et al. , Biomed. Microdev. 9 , 123 ( 2007 ) . Crossref, Google Scholar
J. W. Song et al. , Anal. Chem. 77 , 3993 ( 2005 ) . Crossref, Google Scholar
W. Zheng et al. , Lab. Chip. 12 , 3441 ( 2012 ) . Crossref, Google Scholar
C. S. Simmons et al. , J. Micromech. Microeng. 21 , 54016 ( 2011 ) . Crossref, Google Scholar
J. Zhou and Y. C. Fung , Proc. Natl. Acad. Sci. USA 94 , 14255 ( 1997 ) . Crossref, Google Scholar
W. Tan et al. , Biomed. Microdev. 10 , 869 ( 2008 ) . Crossref, Google Scholar
D. N. Ku et al. , Arteriosclerosis 5 , 293 ( 1985 ) . Crossref, Google Scholar
J. Atencia and D. J. Beebe , Lab. Chip. 6 , 567 ( 2006 ) . Crossref, Google Scholar
R. Estrada et al. , Anal. Chem. 83 , 3170 ( 2011 ) . Crossref, Google Scholar
R. Estrada et al. , Biomicrofluidics 5 , 32006 ( 2011 ) . Crossref, Google Scholar
O. F. Khan and M. V. Sefton , Biomed. Microdev. 13 , 69 ( 2011 ) . Crossref, Google Scholar
A. P. McGuigan and M. V. Sefton , Proc. Natl. Acad. Sci. USA 103 , 11461 ( 2006 ) . Crossref, Google Scholar
F. Shen et al. , Arterioscler Thromb. Vasc. Biol. 28 , 2035 ( 2008 ) . Crossref, Google Scholar
J. K. Tsou et al. , Microcirculation 15 , 311 ( 2008 ) . Crossref, Google Scholar
H. J. Ting et al. , Circ. Res. 100 , 381 ( 2007 ) . Crossref, Google Scholar
G. P. van Nieuw Amerongen et al. , Circ. Res. 83 , 1115 ( 1998 ) . Crossref, Google Scholar
A. J. Huang et al. , J. Cell. Physiol. 135 , 355 ( 1988 ) . Crossref, Google Scholar
E. W. Young et al. , Anal. Chem. 82 , 808 ( 2010 ) . Crossref, Google Scholar
N. J. Douville et al. , Anal. Chem. 82 , 2505 ( 2010 ) . Crossref, Google Scholar
P. A. Vogel et al. , Anal. Chem. 83 , 4296 ( 2011 ) . Crossref, Google Scholar
I. K. Zervantonakis et al. , Proc. Natl. Acad. Sci. USA 109 , 13515 ( 2012 ) . Crossref, Google Scholar
J. W. Song and L. L. Munn , Proc. Natl. Acad. Sci. USA 108 , 15342 ( 2011 ) . Crossref, Google Scholar
C. Kim et al. , Lab. Chip. 12 , 2942 ( 2012 ) . Crossref, Google Scholar
M. Tsai et al. , J. Clin. Invest. 122 , 408 ( 2012 ) . Crossref, Google Scholar
N. Korin et al. , Science 337 , 738 ( 2012 ) . Crossref, Google Scholar
L. K. Fiddes et al. , Biomaterials 31 , 3459 ( 2010 ) . Crossref, Google Scholar