Research ArticleFree Access

Experimental study on the effects of Kursi Ziyabet on the rat model of diabetes mellitus

Alimjan Parhat

College of Xinjiang Uyghur Medicine, Hotan, Xinjiang 848000, P. R. China

Key Laboratory of Uyghur Medicine Research, College of Xinjiang Uyghur Medicine, Hotan, Xinjiang 848000, P. R. China

Alimjan Parhat and Haibaier Huojiaaihemaiti contributed equally to this work.

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Haibaier Huojiaaihemaiti

College of Xinjiang Uyghur Medicine, Hotan, Xinjiang 848000, P. R. China

Key Laboratory of Uyghur Medicine Research, College of Xinjiang Uyghur Medicine, Hotan, Xinjiang 848000, P. R. China

Alimjan Parhat and Haibaier Huojiaaihemaiti contributed equally to this work.

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Nabijan Mohammadturusn

College of Xinjiang Uyghur Medicine, Hotan, Xinjiang 848000, P. R. China

Key Laboratory of Uyghur Medicine Research, College of Xinjiang Uyghur Medicine, Hotan, Xinjiang 848000, P. R. China

E-mail Address: nabijanm@126.com

Corresponding authors.

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Mammat Nurahmat

College of Xinjiang Uyghur Medicine, Hotan, Xinjiang 848000, P. R. China

Key Laboratory of Uyghur Medicine Research, College of Xinjiang Uyghur Medicine, Hotan, Xinjiang 848000, P. R. China

E-mail Address: 1830468427@qq.com

Corresponding authors.

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https://doi.org/10.1142/S2575900019500010Cited by:0 (Source: Crossref)

Abstract

Objective: To evaluate the hyperglycemic effects of Kursi Ziyabet (KZ) tablets on the rat models of diabetes mellitus.

Methods: In total, 58 male SD rats were assigned randomly to six groups. All except the normal group were transformed into experimental diabetes mellitus rat models by injecting streptozocin. The hyperglycemic effect and the mechanism of Ziyabet were evaluated by body weight, food and water intake, fasting blood sugar, and related parameters by measuring the oxidative stress-related factors and lipid metabolism indicator level by the corresponding kits using the rat experimental models.

Results: Compared with the model group, body weight markedly increased after 3–6 weeks of intragastric administration of Ziyabet tablets ( $p < 0.01$ $p < 0.01$ ), while the water intake significantly decreased in the same period of time ( $p < 0.05$ $p < 0.05$ ). Food intake and fasting blood sugar level also decreased with the high dosage of Ziyabet tablets ( $p < 0.05$ $p < 0.05$ ). There is no significant difference in pancreas’ MDA content of the Ziyabet groups when compared to the model group ( $p > 0.05$ $p > 0.05$ ), while significant increase in SOD level was observed in high-dosage KZ group ( $p < 0.05$ $p < 0.05$ ). The blood serum insulin and free fatty acid level also decreased in the high-dosage KZ group compared with the model group ( $p < 0.05$ $p < 0.05$ ).

Conclusion: We conclude that Ziyabet tablets demonstrated protective effects on the diabetic rat models.

Keywords:

References

1. Cassidy F, Ahearn E, Carroll BJ. Elevated frequency of diabetes mellitus in hospitalized manic-depressive patients. Am J Psychiatry 1999; 156(9) :1417–20. Crossref, Google Scholar
2. Etxeberria U, de la Garza AL, Campión J, Martínez JA, Milagro FI. Antidiabetic effects of natural plant extracts via inhibition of carbohydrate hydrolysis enzymes with emphasis on pancreatic alpha amylase. Expert Opin Ther Targets 2012; 16 :269–97. Crossref, Google Scholar
3. Liu Q, Liu S, Gao L, et al. Anti-diabetic effects and mechanisms of action of a Chinese herbal medicine preparation JQ-R in vitro and in diabetic KK^Ay mice. Acta Pharm Sin B 2017; 7(4) :461–9. Crossref, Google Scholar
4. Li WL, Zheng HC, Bukuru J, De Kimpe N. Natural medicines used in the traditional Chinese medical system for therapy of diabetes mellitus. J Ethnopharmacol 2004; 92(1) :1–21. Crossref, Google Scholar
5. Pharmacopoeia Committee of the Ministry of Health of the People’s Republic of China. In: Pharmaceutical Standards of the Ministry of Health of the People’s Republic of China. Ürümqi: Xinjiang Science and Technology Health Publishing House, 1999:162. Google Scholar
6. Li G, Luo X. Experimental study on acute toxicity of Jiangtang Ziyabiti tablets. Xinjiang Med Sci 2012; 42(2):12–3. Google Scholar
7. Wu X, Luo Y, Xu J, et al. TCM constitutional characteristics of type 2 diabetes mellitus and its relationship with insulin resistance and secretion. J Guangzhou Univ Tradit Chin Med 2013; 30(3) :312–7. Google Scholar
8. Bradley C, Speight J. Patient perceptions of diabetes and diabetes therapy: Assessing quality of life. Diabetes Metab Res Rev 2002; 18 :S64–9. Crossref, Google Scholar
9. Koopmanschap M, CODE-2 Advisory Board. Coping with Type II diabetes: The patient’s perspective. Diabetologia 2002; 45 :S18–22. Crossref, Google Scholar
10. Sano R, Miki T, Suzuki Y, et al. Analysis of the insulin-sensitive phosphodiesterase 3B gene in type 2 diabetes. Diabetes Res Clin Pract 2001; 54 :79–88. Crossref, Google Scholar
11. Liu L, Tang D, Zhao H, Xin X, Aisa HA. Hypoglycemic effect of the polyphenols rich extract from Rose rugosa Thunb on high fat diet and STZ induced diabetic rats. J Ethnopharmacol 2017; 200 :174–81. Crossref, Google Scholar
12. Jing W, Chunhua M, Shumin W. Effects of acteoside on lipopolysaccharide-induced inflammation in acute lung injury via regulation of NF- $κ$ $κ$ B pathway in vivo and in vitro. Toxicol Appl Pharmacol 2015; 285 :128–35. Crossref, Google Scholar
13. Aizezi R, Abudureheman S, Wei J, et al. Uygur medical classification of complex diseases and prethrombotic state. Chin J Tradit Chin Med Inf 2009; 16(2):23–5. Google Scholar
14. Maimaitikasimu, Uygur medical treatment and recognition of diabetic foot disease. Chin J Ethn Med 2001; 2001(1):14–6. Google Scholar