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LncRNAs: Master Regulators in Disease and Cancer

Laboratory of NFκB Signaling, Institute of Molecular and Cell Biology (IMCB), A*STAR (Agency for Science, Technology and Research), Singapore 138673, Singapore

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Vinay Tergaonkar

Laboratory of NFκB Signaling, Institute of Molecular and Cell Biology (IMCB), A*STAR (Agency for Science, Technology and Research), Singapore 138673, Singapore

Department of Pathology, Yong Loo Lin School of Medicine, National University of Singapore (NUS), Singapore 117597, Singapore

E-mail Address: vinayt@imcb.a-star.edu.sg

Corresponding author.

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https://doi.org/10.1142/S2591722620400062Cited by:2 (Source: Crossref)

Abstract

Long non-coding RNA (lncRNA) is a new class of endogenous molecules identified in recent years. Studies on the cancer transcriptome have identified a number of lncRNAs with distinct expression patterns in different types of cancer, indicating that this populous group of molecules can modulate cancer progression. In addition, advances in revealing the molecular principles of cancer-associated lncRNAs made them amenable for therapeutic intervention. Although more than 50,000 lncRNAs have been identified, their functions in cellular homeostasis and pathophysiological processes remain largely uncharacterized. In this review, we summarize cancer-related lncRNAs that have been identified in recent years and discuss their mechanistic roles as oncogenes or tumor suppressors. These findings provide insights into clinical application of lncRNAs as biomarkers or therapeutic targets.

Keywords:

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