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ORAL PRESENTATION: Reproductive GeneticsOpen Access

#235 : The Impact of Endometrial Scratch Performed in Mid-Luteal Phase on the Endometrium Whole Genome Transcriptomic Profiles in Following Menstrual Cycle

    https://doi.org/10.1142/S2661318223743503Cited by:0 (Source: Crossref)
    This article is part of the issue:

    Background and Aims: To verify whether endometrial scratch in mid-luteal phase affect the genomic characteristics of peri-implantation endometrium in the following cycle.

    Method: A Retrospectively self-control cohort study was conducted in a university assisted reproductive unit. A total of eight women with recurrent implantation failure were included. Each participant had endometrial biopsy twice, one biopsy was done on day LH+7 in a natural cycle, and the second biopsy was performed on day LH+7 of the following cycle. R package was used for identifying differentially expressed genes between the first biopsy group and the second biopsy group, and for gene set enrichment analysis.

    Results: The paired sample showed no significant difference in gene expression profiles of endometrium before and after endometrial scratch.

    Conclusion: It suggests that endometrial scratch performed during previous mid-luteal phase did not affect the genomic profiles of endometrium on day LH+7 in women with recurrent implantation failure.

    Publisher's Note:

    This article contains the abstract sections only.