In this paper, we introduce the notion of (θ1, θ2, θ3, ϕ)-derivations on Hilbert C*-modules. Moreover, we investigate the generalized Hyers–Ulam–Rassias stability, Isac–Rassias type stability and superstability of (θ1, θ2, θ3, ϕ)-derivations on Hilbert C*-modules.