Amines

The following sections are included:

• General

• Synthesis

  • Aliphatic Amines

    • Alkylation Reactions

      • Of Ammonia

      • Primary Amines - The Gabriel Synthesis

      • Secondary Amines From Trifluoromethanesulphonamides

      • Tertiary Amines

    • Reductive Methods

      • Of Amides

      • Of Nitro Compounds

      • Of Azides

      • Of Nitriles, Oximes

      • Reduction of Imines

        • The Eschweiler-Clark Reaction

        • Use of B(CN)H₃^- as Hydride Source

    • Hydrolytic Methods

    • Rearrangements

      • The Hofmann Elimination for RCONH₂ Species

      • The Curtius Rearrangement

      • The Lossen Rearrangement

      • The Schmidt Rearrangement

      • The Beckmann Rearrangement

• Reactions of Amines

  • Basicity and Nucleophilicity

    • Alkylation

    • Acylation - Formation of Amides

    • Halogenation

      • Aliphatic Amines

      • Aromatic Amines

    • Nitrosation

      • Primary Amines

        • R = Aryl

        • R = Alkyl

      • Secondary Amines

        • Alkyl Amines

        • Aryl Amines

      • Tertiary Amines

    • Reactions With Carbonyl Compounds

      • Primary Amines

      • Secondary Amines

      • Tertiary Amines

    • Reaction of 1° Amines With Dichlorocarbene - Formation of Isonitriles

  • Oxidation Reactions

    • Oxidation Only at Nitrogen - Use of Peracids

      • Primary Amines

      • Secondary Amines

      • Tertiary Amines

    • Oxidation at the α-Carbon - Dehydrogenation

  • Deprotonation