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The Role of Fibrocytes in Post-burn Hypertrophic Scarring

    https://doi.org/10.1142/9789812706690_0005Cited by:1 (Source: Crossref)
    Abstract:

    The following sections are included:

    • Introduction

    • Altered Structure and Composition of the Extracellular Matrix of Hypertrophic Scars

    • A Th2 Polarized Immune Response in Hypertrophic Scar

    • Dysregulated Apoptosis in Hypertrophic Scar

      • Apoptosis in the Resolution of Inflammation

      • Delayed Fibroblast and Myofibroblast Apoptosis in Hypertrophic Scar

    • Increased Levels of the Profibrotic Growth Factors TGF-β and CTGF in Hypertrophic Scar

    • Hypertrophic Scarring is Associated with Blood Borne Fibrocytes

    • Increased Numbers of Fibrocytes can be Cultured from the Blood of Burn Patients

    • Establishment of LSP-I as a Fibrocyte Marker

    • Increased Numbers of Fibrocytes in Post-burn Hypertrophic Scar

    • Potential Interaction of Fibrocytes and Endothelial Cells

    • Possible Interactions of Fibrocytes and Fibroblasts

    • Elevated TGF-β and CTGF mRNA Levels in Burn Patient Fibrocytes

    • Fibrocytes may Contribute to the Myofibroblast Population

    • Possible Role of Fibrocytes in the Polarized Th2 Immune Response

    • Proposed Role of Fibrocytes in Hypertrophic Scar Formation

    • Summary and Prospects for FutureWork

    • Acknowledgments

    • References