The Role of Fibrocytes in Post-burn Hypertrophic Scarring
The following sections are included:
Introduction
Altered Structure and Composition of the Extracellular Matrix of Hypertrophic Scars
A Th2 Polarized Immune Response in Hypertrophic Scar
Dysregulated Apoptosis in Hypertrophic Scar
Apoptosis in the Resolution of Inflammation
Delayed Fibroblast and Myofibroblast Apoptosis in Hypertrophic Scar
Increased Levels of the Profibrotic Growth Factors TGF-β and CTGF in Hypertrophic Scar
Hypertrophic Scarring is Associated with Blood Borne Fibrocytes
Increased Numbers of Fibrocytes can be Cultured from the Blood of Burn Patients
Establishment of LSP-I as a Fibrocyte Marker
Increased Numbers of Fibrocytes in Post-burn Hypertrophic Scar
Potential Interaction of Fibrocytes and Endothelial Cells
Possible Interactions of Fibrocytes and Fibroblasts
Elevated TGF-β and CTGF mRNA Levels in Burn Patient Fibrocytes
Fibrocytes may Contribute to the Myofibroblast Population
Possible Role of Fibrocytes in the Polarized Th2 Immune Response
Proposed Role of Fibrocytes in Hypertrophic Scar Formation
Summary and Prospects for FutureWork
Acknowledgments
References