MATHEMATICAL AND COMPUTER MODELING OF MOLECULAR-GENETIC MECHANISMS OF LIVER CELLS INFECTION BY HEPATITIS B VIRUS

This work deals with some results of the analysis of molecular-genetic mechanisms of interconnected activity between hepatocytes and hepatitis B virus (HBV) based on mathematical modeling. The functional-differential equations of functioning regulatory mechanisms (regulatorika) of molecular-genetic systems of cells in multicellular organisms are used as equations class for the quantitative analysis of activity regularities of "hepatocytes-HBV" genetic system. Results obtained during qualitative studies show that there are different scenarioes for fulfilling the infectious process on cellular level at HBV, including symbiotical coexistence between hepatocyte and virus, also periodical excitement of the virus infection.