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IDEAL PROTEIN FORMS AND THEIR APPLICATION TO DE-NOVO STRUCTURE PREDICTION
This work is supported by the medical research council (uk) and the research council of norway (functional genomics programme FUGE).
https://doi.org/10.1142/9789812708779_0015Cited by:0 (Source: Crossref)
Abstract:
An abstract representation, similar to a Periodic Table, was used to generate a large number of idealised protein folds. Each of these was taken as a framework onto which a variety of predicted secondary structures were mapped and the resulting models constructed at a more detailed level. The best of these were refined and rescored. On a set of five proteins, the correct fold was scored highly in each with the top models having a low root-mean-square deviation from the known structure.
