MULTI-OBJECTIVE EVOLUTIONARY APPROACH TO AB INITIO PROTEIN TERTIARY STRUCTURE PREDICTION

The Protein Structure Prediction (PSP) problem aims at determining protein tertiary structure from its amino acids sequence. PSP is a computationally open problem. Several methodologies have been investigated to solve it. Two main strategies have been employed to work with PSP: homology and ab initio prediction. This paper presents a Multi-Objective Evolutionary Algorithm (MOEA) to PSP problem using an Ab initio approach. The proposed MOEA uses dihedral angles and main angles of the lateral chains to model a protein structure. This article investigates advantages of multi-objective evolutionary approach and discusses about methods and other approaches to the PSP problem.