The Importance of Target Selection Strategies in Structural Biology

The following sections are included:

• Introduction

• Global Structural Efforts and their Target Selection Strategies

• Selecting and Prioritizing Targets

• The Protein Structure Initiative (PSI)

  • Summary of Target Selection and Results from PSI Centers

  • PSI Targets from Minimal Organisms

  • PSI Targets from Extremophiles

  • PSI Targets from Pathogens

  • PSI Targets from Eukaryotic Organisms

• SPINE – Structural Proteomics in Europe Project, Function-based Target Selection

  • Target Selection in SPINE

  • SPINE Studies on Bacillus anthracis

  • SPINE Studies on Viral Pathogens

  • SPINE Studies on Human Proteins of High Biomedical Value

• SGC – Structural Genomics Consortium

  • Target Selection in the SGC

• Expanding the Target List

• References