The Impact of 3D Structures on a Protein Knowledgebase: From Proteins to Systems

The following sections are included:

• Introduction

• UniProtKB: Facilitating Access to 3D-Structures

• Representation of Taxonomic Groups in PDB and in UniProtKB/Swiss-Prot

• Integrating 3D-Structures with Functional Annotation

  • The Challenge of Presenting Complex Data I — General Information

  • The Challenge of Presenting Complex Data II– 3D-Structures and Sequence Annotation

    • Topology of membrane proteins

    • Annotation of ligand binding sites

    • Active site residues

    • Covalent modifications

• Combining 3D-Structures with Protein Sequences

• Outlook: Function Prediction for Uncharacterized and Hypothetical Proteins

• Acknowledgments

• References