Critical Molecules in Bone Development and Genetic Bone Diseases

The following sections are included:

• WNT/LRP5

  • Wnt/β-Catenin Signaling

  • LRP5 and Its Homolog

  • LRP5 Receptor and OPPG and HBM Syndromes

    • LRP5 and OPPG

    • LRP5 and HBM Syndromes

    • LRP5 and BMD Variations

  • Wnt/LRP5 Signaling Pathway in Bone Metabolism

    • Osteoblast: The Major Target of Wnt Signaling

    • Osteoclast: The Promising Wnt Signaling Target

• RUNX2

  • Runx2, a Bone-Specific Transcription Factor

  • Runx2 Target Genes

  • Runx2 and Bone Formation

    • Runx2 in Osteoblast Proliferation

    • Runx2 in Osteoblast Differentiation

    • Runx2 in Chondrocyte Hypertrophy

    • Runx2 in Osteoclast Formation

  • Transcriptional and Posttranslational Control of Runx2

    • Transcriptional Control of Runx2

    • Posttranslational Control of Runx2

  • Runx2-Related Diseases

    • Human Cleidocranial Dysplasia (CCD) Syndrome

    • Association of Runx2 Polymorphisms with BMD

• PTH/PTHrP

  • PTH/PTHrP and Their Receptors

  • PTH: A Hormone with Dual Functions

  • PTHrP: The Bone-Specific Peptide

  • Genetic Disorders Caused by PTHR1 Mutations

• REFERENCES