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Chapter 3: The Effects of Nanoparticles on Dendritic Cells

    https://doi.org/10.1142/9789813140479_0003Cited by:0 (Source: Crossref)
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    Abstract:

    Dendritic cells (DCs) are professional antigen-presenting cells (APCs) that induce the primary immune response and are responsible for the activation of T and B cells. The main function of DCs is to serve as a link between the innate and adaptive immunity. Understanding the role of DCs in controlling the immune system can provide powerful tools for the successful manipulation of immune cells to optimize vaccine delivery and to expand possibilities of immunotherapeutic approaches. Nanoparticle (NP) applications for targeted delivery of antigens to the DCs is a promising strategy for vaccine development. Herein, I present an overview of different NPs and approaches of their delivery to DCs, review the interaction between NPs and DCs, NP effects on the maturation, activation, and function of DCs, and outline future directions for NP-enhanced immune control to further foster the development of successful vaccination strategies and cancer immunotherapies.